Description of Individual Course Units
Course Unit CodeCourse Unit TitleType of Course UnitYear of StudySemesterNumber of ECTS Credits
9303135012006Rekombinant DNA TechnologyCompulsory1112
Level of Course Unit
Second Cycle
Objectives of the Course
This Lecture aims to provide advanced knowledge for Graduate Pharmacy students about the processes such as transferring genetic information from one organism to another for production of pharmaceuticals. The students are aimed to gain the ability of molecular approach in pharmaceutical applications. The subjects are discussed in relation to pharmaceutical aspects of the human genome project and the students learn the methods, which are applied in the pharmaceutical area as well as commercial and ethical issues of Gene Engineering.
Name of Lecturer(s)
Prof. Dr. Zeki Topçu-Assoc. Prof. Dr. Gulten Kantarcı
Learning Outcomes
1Comprehension of basic recombinant biotechnology techniques
2Gaining of molecular genetic fundamentals and interpetation.
3İmprovement of personal vision on biotechnology applications, and improving research capabilities on pharmacutical biotechnology.
4
5
Mode of Delivery
Face to Face
Prerequisites and co-requisities
None
Recommended Optional Programme Components
None
Course Contents
Recombinant DNA Technology, Molecular Research Procedures, Manipulation of gene expression in prokaryotes, Molecular diagnostics: Immunological diagnostic procedures, Human Somatic Gene therapy: Regulation and patenting Gene Engineering: Patenting biotechnology inventions, ethical considerations.
Weekly Detailed Course Contents
WeekTheoreticalPracticeLaboratory
1Restriction endonucleases
2Vectors
3Genomic and cDNA library
4Genetic transformation
5DNA sequencing techniques
6Polymerase chain reaction
7First exam
8Monoclonal antibodies
9Gene expression from strong and regulatable promoters
10Binding of clonned genes to expressed vectors
11Fusion proteins increasing protein stability
12DNA diagnostic systems
13Ex vivo/in vivo gene therapy
14Antisense therapy
15Patenting biotechnology inventions, ethical considerations
16Final exam
Recommended or Required Reading
Glick, B. R. And Pasternak, J. J. ‘Molecular Biotechnology’, ASM Press 1994, Washington D.C.
Planned Learning Activities and Teaching Methods
Activities are given in detail in the section of "Assessment Methods and Criteria" and "Workload Calculation"
Assessment Methods and Criteria
Term (or Year) Learning ActivitiesQuantityWeight
SUM0
End Of Term (or Year) Learning ActivitiesQuantityWeight
SUM0
SUM0
Language of Instruction
Turkish
Work Placement(s)
None
Workload Calculation
ActivitiesNumberTime (hours)Total Work Load (hours)
Attending Lectures14456
Self Study8432
Individual Study for Homework Problems6636
Individual Study for Mid term Examination11212
Individual Study for Final Examination11414
TOTAL WORKLOAD (hours)150
Contribution of Learning Outcomes to Programme Outcomes
PO
1
PO
2
PO
3
PO
4
PO
5
PO
6
PO
7
PO
8
PO
9
PO
10
PO
11
PO
12
LO14 3  4   3  
LO2 4  3  5    
LO34  3  333   
LO4            
LO5            
* Contribution Level : 1 Very low 2 Low 3 Medium 4 High 5 Very High
 
Ege University, Bornova - İzmir / TURKEY • Phone: +90 232 311 10 10 • e-mail: intrec@mail.ege.edu.tr