Description of Individual Course Units
Course Unit CodeCourse Unit TitleType of Course UnitYear of StudySemesterNumber of ECTS Credits
9303135092006Advenced Moleculer BiologyElective116
Level of Course Unit
Second Cycle
Objectives of the Course
“Molecular Biology” is a continuation of undergarduate course entitled “Introduction to Molecular Biology” with a particular emphasis on nucleic acids. DNA and RNA molecules are covered in a detailed aspect and regulation of gene expression is particularly emphasized. The students are aimed to gain a general understanding cell-cycle control, gene expression and cell-to-cell signaling pathways in relation cancer. The students will also instructed on DNA and RNA manipulations.
Name of Lecturer(s)
Prof. Dr. Zeki Topçu
Learning Outcomes
Mode of Delivery
Face to Face
Prerequisites and co-requisities
None
Recommended Optional Programme Components
None
Course Contents
Molecular Structure of Genes and Chromosomes, Nucleic Acid Synthesis, Translation, DNA repair and recombination, DNA damage and repair, and their role in carcinogenesis, DNA topology and topoisomerases/DNA telomeres and telomerases.
Weekly Detailed Course Contents
WeekTheoreticalPracticeLaboratory
1Human genome project
2Molecular Anatomy of Genes and Chromosomes: Geometry of nucleic acids, DNA and RNA secondary structures.
3Molecular anatomy
4Regulation of Gene Expression: Transcriptional mechanisms in prokaryotes and eukaryotes, transcriptional and translational control of gene expression, post-translational modifications.
5Translation
6DNA Repair and Recombination: DNA damage and repair, and their role in carcinogenesis, recombination between homologus and non-homologus DNA sites.
7DNA Repair and Recombination: DNA damage and repair, and their role in carcinogenesis, recombination between homologus and non-homologus DNA sites.
8First Exam
9DNA topology and topoisomerases/DNA telomeres and telomerases. Secondary structure of DNA, telomere shortening and replicative senescence
10Oncogenic Transformation: Proto-oncogenes and tumor-suppressor genes, oncogenic mutations affecting cell proliferation
11Basic Experimental Techniques in Molecular Biology: DNA and RNA isolation, DNA amplification.
12Basic Experimental Techniques in Molecular Biology: determination of nucleotide sequences.
13Restrictional analyses.
14Scientific article
15Scientific article
16Final Exam
Recommended or Required Reading
“Molecular Cell Biology” Freeman Press, 2000 New York
Planned Learning Activities and Teaching Methods
Activities are given in detail in the section of "Assessment Methods and Criteria" and "Workload Calculation"
Assessment Methods and Criteria
Term (or Year) Learning ActivitiesQuantityWeight
SUM0
End Of Term (or Year) Learning ActivitiesQuantityWeight
SUM0
SUM0
Language of Instruction
Turkish
Work Placement(s)
None
Workload Calculation
ActivitiesNumberTime (hours)Total Work Load (hours)
Attending Lectures14342
Observation14228
Criticising Paper11010
Individual Study for Mid term Examination166
Individual Study for Final Examination11111
TOTAL WORKLOAD (hours)97
Contribution of Learning Outcomes to Programme Outcomes
PO
1
PO
2
PO
3
PO
4
PO
5
PO
6
PO
7
PO
8
PO
9
PO
10
PO
11
PO
12
* Contribution Level : 1 Very low 2 Low 3 Medium 4 High 5 Very High
 
Ege University, Bornova - İzmir / TURKEY • Phone: +90 232 311 10 10 • e-mail: intrec@mail.ege.edu.tr