Description of Individual Course Units
Course Unit CodeCourse Unit TitleType of Course UnitYear of StudySemesterNumber of ECTS Credits
9105045352000Laboratory Techniques for Nuclear Analyses IElective114
Level of Course Unit
Second Cycle
Language of Instruction
Objectives of the Course
The objective of this course is to supply the multi-disciplinary students with the basic concepts of radiation, the principles of working with radioactive materials, knowledge of the measurement and analysis techniques and skills in the nuclear field, and analytical considering.
Name of Lecturer(s)
Mahmoud A. A. ASLANİ, Ceren KÜTAHYALI, Müslüm Murat SAÇ, Fazilet Zümrüt BİBER MÜFTÜLER
Learning Outcomes
1Be able to assemble the relationship between radioactivity and modern analytic methods.
2Be able to comprehend the basic concepts and principles of nuclear analytical methods.
3Be able to use radiation measurement and systems.
4Be able to observe the studies in nuclear field.
5Be able to study in the field of labeling of new molecules with radionuclide and design radiopharmaceuticals.
6Be able to observe the new developments in the field of health and natural sciences.
7Be able to work with radioactive materials.
8Be able to use the nuclear techniques in order to contribute to human health and prosperity.
9Be able to gain applicable abilities of nuclear techniques in the field of natural sciences and engineering.
Mode of Delivery
Face to Face
Prerequisites and co-requisities
Recommended Optional Programme Components
Course Contents
The basic and fundamental concepts of radiation and measurement systems. The regulations of working with radioactive materials. Unites of radioactivity. Identification of radioactive raw materials. The physical and chemical processes applied on the uranium ore. Basic principles of UV-Visible spectrophotometer. The laser fluorimetric uranium analyzer. Gamma spectrometer. The basics of alpha and beta counters. Radioactive analysis of environmental samples. The nuclear fuel cycle and waste management. Basic principles of ICP-OES, Surface Area Analyzer and microwave digestion. Novel Radiolabeled molecules and design of radiopharmaceuticals. Radiolabeling. Techniques of Radiolabeling. Techniques of labeling with Tc-99m. Quality control studies using chromatographic methods (High Performance Liquid Chromatography (HPLC). High Performance Liquid Radio Chromatography (HPLRC). Thin Layer Liquid Chromatography (TLC). Thin Layer Liquid Radio Chromatography (TLRC), paper Electrophoresis). Basic equipments of nuclear spectroscopy systems and nuclear imaging systems. Introduction of the interaction with matter of radiation, Measurement systems and operating principles (G-M, Scintillation and semiconductor detectors operating principles), The field study and sampling (determine to location and geographic information, land plots, environmental characteristics), Radon measurement techniques (LR115 solid-state nuclear track detector, radon measurements with collector method in waters and soils), 3D graphic representation of data distribution.
Weekly Detailed Course Contents
1The regulations of working with radioactive materials. Units. Uranium ore, crushing, sieving, and leaching process.Assisted laboratory work
2Chemical and radiochemical separation techniques of uranium. Sorption, solvent extraction, ion Exchange, precipitation.Assisted laboratory work
3Measurement of uranium using UV-Visible spectrophotometer in aqueous solutions. Demonstration of laser fluorimetric uranium analyzer. Presentation of gamma spectroscopy.Assisted laboratory work
4The principles of using alpha counter in radioactivity analysis of environmental samples.Assisted laboratory work
5Nuclear fuel cycle, leaching of uranium by microwave digestion equipment.Assisted laboratory work
6The principles of working with ICP-OES for analysis of uranium, the analysis of uranium leaching solution.Assisted laboratory work
7Classification of nuclear waste, nuclear waste management.Assisted laboratory work
8Mid-term Exam
9When working with radioactive materials requiring consideration of issues, radiation level control by using area monitor, Using dosimetry, Cd (Te) detector and TLC scanner and theirs basic features.Assisted laboratory work
10Basic equipments of nuclear spectroscopy systems and nuclear imaging systems.Assisted laboratory work
11Chromatographic methods, High Performance Liquid Chromatography (HPLC), High Performance Liquid Radio Chromatography (HPLRC), Thin Layer Liquid Chromatography (TLC), Thin Layer Liquid Radio Chromatography (TLRC), paper Electrophoresis.Assisted laboratory work
12Techniques of labeling with Tc-99m, quality control studies of labeling compounds with Tc-99m using chromatographic methods.Assisted laboratory work
13The fundamental topics of radiation, The introduction of detectors, GM, scintillation, semiconductor detectors solid- LR115state nuclear track detector operating principles.Assisted laboratory work
14Field sampling procedures (Grids of plots, location and registration of geographic information, environmental factors, vertical and surface soil sampling methods.Assisted laboratory work
15Measurement of radon and radium in soil and water with collector method, processing and graphical representation of the data and, the surface distribution of the dataAssisted laboratory work
16Final Exam.
Recommended or Required Reading
Textbook/Recommended Reading : 1. Benedict M., Pigford T. H., Levi H. W., Nuclear Chemical Engineering, Second Edition, McGraw-Hill Book Company, 1981. 2. Friendlander G., Kennedy J. W., Macias E. S., Miller J. M., Nuclear and Radiochemistry, 3rd Ed., John Wiley and Sons, 1981 3. Gregg,S.J., Sing K.S.W. , Adsorption, Surface Area and Porosity, Academic Press, 1982. 4.Theobald, A.E., Radiopharmaceuticals using radioactive compounds in pharmaceutics and medicine, Ellis Horwood Limited, 1989. 5. Ünak P., Radyofarmasötikler, 2002. 6. Tsoulfanidis, N, Measurement and Detection of Radiation, Hemisephere Publishing Corp., 1983. 7. Yener, G. “Nükleer Radyasyon Fiziği Ders Notları I, 2003. 8. Cothern, C., Smith, J. E., Environmental Radon. Environmental Science Research, Volume 35, A Division of Plenum Publishing Corporation 233 Spring Street, Newyork, N.Y., 1987. 9. National Research Council,. Comparative Dosimetry of Radon in Mines and Homes. Washington D.C. ,1991. 10. Nokaman, E., Radyoaktif Hammaddeler Jeolojisi. Maden Tetkik ve Arama Enstitüsü Yayınları, Eğitim Serisi No:20, Ankara, 1979.
Planned Learning Activities and Teaching Methods
Activities are given in detail in the section of "Assessment Methods and Criteria" and "Workload Calculation"
Assessment Methods and Criteria
Term (or Year) Learning ActivitiesQuantityWeight
End Of Term (or Year) Learning ActivitiesQuantityWeight
Work Placement(s)
Workload Calculation
ActivitiesNumberTime (hours)Total Work Load (hours)
Midterm Examination122
Final Examination122
Attending Lectures14114
Team/Group Work14228
Report Presentation14114
Individual Study for Mid term Examination11010
Individual Study for Final Examination11515
Contribution of Learning Outcomes to Programme Outcomes
LO1    5545  5
LO2    5 54   
LO3  5 55 44  
LO4  4 555 5 5
LO5    555   5
LO6  555555 55
LO7  555  5555
LO8   5 5  4 5
* Contribution Level : 1 Very low 2 Low 3 Medium 4 High 5 Very High
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