Description of Individual Course Units
Course Unit CodeCourse Unit TitleType of Course UnitYear of StudySemesterNumber of ECTS Credits
300003452007PHARMACEUTICAL TECHNOLOGY ICompulsory356
Level of Course Unit
First Cycle and Second Cycle
Objectives of the Course
The objectives of this course are, to achieve that students could: comprehend the concept of solid dosage forms and modern drug delivery systems, comprehend the general properties and processes of the powders as the buildingstones of these systems, define all the formulations involved, demonstrate all the ingredients including the excipients of these formulations, comprehend the preparation techniques, comprehend the related calculations, design and prepare different formulations for different administration ways. conduct the control tests on the final products and evaluate them, explain the factors affecting the stability of these systems and evaluate them with the techniques involved.
Name of Lecturer(s)
Prof. Dr. Gökhan Ertan, Prof. Dr. Özgen Özer, Prof. Dr. Ferhan Sevgi, Prof. Dr. Esra Baloğlu, Prof. Dr. Yeşim Karasulu, Doç. Dr. Işık Özgüney, Doç. Dr. Mine Özyazıcı, Yard. Doç. Dr. Mesut Arıcı, Doç. Dr. Sinem Yaprak Karavana, Doç. Dr. Evren Homan Gökçe, Doç. Dr. Emel Öykü Çetin Uyanıkgil, Doç. Dr. İpek Eroğlu
Learning Outcomes
1To comprehend the basic properties of the powders, to be able to explain the processes such as sieving, grinding and filling, to be able to list the required properties of the powders, explain the tests involved.
2To be able to give information about the structure, types, preparation and filling of gelatin capsules, to be able to prepare soft gelatin capsules and to be able to fill hard gelatin capsules.
3To be able to define granules and to be able to prepare them, to be able to conduct the control tests, to be able to explain the types of granules
4To be able to define tablets, to be able to explain the properties of the excipients, comprehend the related calculations, to be able to prepare tablets, to be able to evaluate and solve the problems occurring during the production of tablets, to be able to conduct quality control tests and classify the tablet types
5To be able to classify the controlled release systems, comprehend the release mechanism of modified tablets
Mode of Delivery
Face to Face
Prerequisites and co-requisities
None
Recommended Optional Programme Components
To attend the final exam, students have to be successful in the laboratory practice
Course Contents
The properties of powders and control tests, The powder obtaining methods, Definition of gelatin capsule: preparation and control tests, Definition of granules and preparation methods, control tests, Definition of tablets: Excipients used in production of tablets, Tablet compression, Factors affecting tablet compression, Tablet preparation methods, Tablet Types, Tablet coating, Controlled Release Systems (CRS): definition and objective, CRS properties, CRS types, CRS mechanism, CRS advantages and disadvantages, Definition of Microparticles and Nanoparticles: Mechanism of action, Preparation Methods, Definition of transdermal therapeutic systems: Mechanism of action and Preparation methods, Definition of implant systems: Mechanism of Action and Preparation Methods, Definition of Nasal preparations; Mechanism of Action and Preparation Methods
Weekly Detailed Course Contents
WeekTheoreticalPracticeLaboratory
1The properties of powders, control tests Preparation of oral powder containing aluminum hydroxide, oral powder containing belladonnae extract, dermal powder containing zinc oxide, cachet including naproxen sodium, cachet including paracetamol, cachet including scopolamine butylbromide and dry powder inhaler containing budesonide.
2The powder obtaining methodsReading and searching papers
3Definition of gelatin capsule:preparation and control testsPrepared powders, microcapsules, microspheres and beads filled into hard gelatin capsules
4Definition of granules and preparation methods, control testsPreparation of granules of fosfomycin trometamol, granules of acetylcystein, granules of magnesium carbonate and test of granules
5Definition of tablets: Excipients used in production of tabletsReading and searching papers
6Tablet compression, preparation methods, types, and coating,Preparation of tablets by direct compression, dry granulation and wet granulation methods. Preparation of watersoluble tablets, chewable tablets, bioadhesive vaginal tablets, fast dispersible tablets and ffervescent tablets. As controls of tablets, weight variation test, hardness test, disintegration test, friability test and dissolution test for tablets.
7Controlled Release Systems (CRS): definition and objectiveReading and searching papers
8CRS properties, CRS typesReading and searching papers
9CRS mechanism, CRS advantages and disadvantagesReading and searching papers
10Definition of Microparticles: Mechanism of Action and Preparation MethodsPreparation of microcapsules including nitrofurantoin by coacervation method, preparation of microspheres containing thiamine hydrochloride by emulsion method, preparation of beads by ionotropic gelation.
11Definition of Nanoparticles: Mechanism of Action and Preparation MethodsReading and searching papers
12Definition of implant systems: Mechanism of Action and Preparation MethodsReading and searching papers
13MIDTERM EXAM
14Definition of transdermal therapeutic systems: Mechanism of Action and Preparation MethodsReading and searching papers
15Definiton of Nasal preparations; Mechanism of Action and Preparation Methods, GMPReading and searching papers
16FINAL EXAM
Recommended or Required Reading
1. Modern Pharmaceutics Second Edition:Revised and Expanded, Ed: Gilbert S. Banker, Christopher T. Rhodes, Marcel Dekker, New York, 1990 2. Dermatological and Transdermal Formulations (Drugs and the Pharmaceutical Sciences), Kenneth A. Walters, Feb 20, 2002 3. drug targeting technology advanced pharmaceutics pharm. Tech. Encylop vol 3-4 4. Drug Targeting Technology: Physical, Chemical and Biological Methods (Drugs and the Pharmaceutical Sciences), Hans Schreier, Aug. 15, 2001 5. Encyclopedia of pharmaceutical technology volume 1-5 6. European Pharmacopoeia 6.0, Council of Europe, Jul 23, 2007 7. Freeze-Drying/Lyophi... Of Pharmaceutical & Biological Products, Second Edition: Revised And Expanded (Drugs and the Pharmaceutical Sciences), Louis Rey, Joan C. May, Jan 21, 2004 8. Handbook of Pharmaceutical Granulation Technology, Second Edition (Drugs and the Pharmaceutical Sciences), Dilip M. Parikh, Aug 30, 2005 9. Hard Capsules: Development - Technology, Ridgway, Jan. 1987 10. Mechanisms of Transdermal Drug Delivery (Drugs and the Pharmaceutical Sciences), Russel O. Potts, Jul 15, 1997 11. Microencapsulation: Methods and Industrial Applications, Second Edition (Drugs and the Pharmaceutical Sciences), Simon Benita 12. Modified-Release Drug Delivery Technology (Drugs and the Pharmaceutical Sciences), Michael J. Rathbone, Michael S. Roberts, and Jonathan Hadgraft, Nov 7, 2002 13. Nanoparticle Technology for Drug Delivery (Drugs and the Pharmaceutical Sciences), Ram B. Gupta, Uday B. Kompella Jan 13, 2006 14. Ophthalmic Drug Delivery Systems, Second Edition: Second Edition, Revised And Expanded (Drugs and the Pharmaceutical Sciences) by Ashim K. Mitra, Mar 25, 2003 15. Pharmaceutical Dissolution Testing by Jennifer J. Dressman, Johannes Kramer, Jul 8, 2005 16. Pharmaceutical Dosage Forms: Tablets, Vol. 1-3, Herbert Lieberman, Leon Lachman, Joseph B. Schwartz, Jun 5, 1989 17. Percutaneous Absorption: Drugs, Cosmetics, Mechanisms, Methods, Fourth Edition (Drugs and the Pharmaceutical Sciences), Robert L. Bronaugh, Howard I. Maibach, Jul 25, 2005 18. Pharmaceutical Extrusion Technology (Drugs and the Pharmaceutical Sciences), Isaac Ghebre-Selassie, Charles Martin,may 1, 2003 19. Physiological Pharmaceutics: Barriers to Drug Absorption, Neena Washington, Clive Washington, Clive Wilson, Dec. 21, 2000 20. Polymeric Drug Delivery Systems (Drugs and the Pharmaceutical Sciences) by Glen S. Kwon (Hardcover - Apr 12, 2005 21. Polymers in Drug Delivery by Ijeoma F. Uchegbu and Andreas G. Schatzlein (Hardcover - May 19, 2006 22. Powder Technology Handbook, Third Edition, Hiroaki Masuda, Ko Higashitani, Hideto Yoshida, Jan 13, 2006 23. Surfactants and Polymers in Drug Delivery (Drugs and the Pharmaceutical Sciences) by Martin Malmsten (Hardcover - Jul 22, 2002 24. The Clinical Research Process in the Pharmaceutical Industry (Drugs and the Pharmaceutical Sciences), G. M. Matoren, Dec 13, 1983 25. Transdermal Drug Delivery Systems: Revised And Expanded (Drugs and the Pharmaceutical Sciences), Jonathan Hadgraft, Oct 29, 2002 26. The Complete Drug Reference, 1992, United States Pharmacopeial Convention Inc. Permission granted, Consumer Reports Books 27. Transnasal Systemic Medications: Fundamentals, Developmental Concepts and Biomedical Assessments, Yie W. Chien Mar. 1985 28. Bioadhesive Drug Delivery Systems: Fundamentals, Novel Approaches, and Development (Drugs and the Pharmaceutical Sciences), Edith Mathiowitz, Donald E. Chickering III, and Claus-Michael Lehr, Jul 13, 1999 29. Liposomes: A Practical Approach (The Practical Approach Series), Vladimir Torchilin and Volkmar Weissig, Aug 7, 2003 30. Modern Farmasötik Teknoloji, F. Acartürk, İ. Ağabeyoğlu, N. Çelebi, T. Değim, Z. Değim, T. Doğanay, S. Takka, F. Tırnaksız, Türk Eczacıları Birliği Eczacılık Akademisi Yayını, 2006 31. Kontrollü salım sistemleri, A. Z. Gürsoy, Kontrollü Salım Sistemleri Derneği, 2002 32. Farmasötik Teknoloji, Temel konular ve dozaj şekilleri, A. Z. Gürsoy, Kontrollü Salım Sistemleri Derneği, 2004
Planned Learning Activities and Teaching Methods
Activities are given in detail in the section of "Assessment Methods and Criteria" and "Workload Calculation"
Assessment Methods and Criteria
Term (or Year) Learning ActivitiesQuantityWeight
Midterm Examination1100
SUM100
End Of Term (or Year) Learning ActivitiesQuantityWeight
Final Sınavı1100
SUM100
Term (or Year) Learning Activities40
End Of Term (or Year) Learning Activities60
SUM100
Language of Instruction
Turkish
Work Placement(s)
None
Workload Calculation
ActivitiesNumberTime (hours)Total Work Load (hours)
Midterm Examination11.51.5
Final Examination12.52.5
Attending Lectures14342
Practice22122
Laboratory10330
Criticising Paper8216
Individual Study for Mid term Examination11717
Individual Study for Final Examination13838
TOTAL WORKLOAD (hours)169.0
Contribution of Learning Outcomes to Programme Outcomes
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* Contribution Level : 1 Very low 2 Low 3 Medium 4 High 5 Very High
 
Ege University, Bornova - İzmir / TURKEY • Phone: +90 232 311 10 10 • e-mail: intrec@mail.ege.edu.tr