Description of Individual Course Units
Course Unit CodeCourse Unit TitleType of Course UnitYear of StudySemesterNumber of ECTS Credits
300003462007PHARMACEUTICAL TECHNOLOGY IICompulsory366
Level of Course Unit
First Cycle and Second Cycle
Objectives of the Course
The objectives of this course are, to achieve that students could: define two-phased drug release systems, know the formation theories of these formulations, comprehend the structure of the two-phased systems, ingredients involved and rheological behaviors, design the formulation of these systems and prepare them, determine the required properties of two-phased systems with characterization methods, explain the stability of these systems and evaluate this phenomenon by different techniques, list the quality control parameters of the obtained systems and evaluate the quality of the systems, to prepare pediatric and geriatric dosage forms and compounding.
Name of Lecturer(s)
Prof. Dr. Gökhan Ertan, Prof. Dr. Özgen Özer, Prof. Dr. Ferhan Sevgi, Prof. Dr. Esra Baloğlu, Prof. Dr. Yeşim Karasulu, Doç. Dr. Işık Özgüney, Doç. Dr. Mine Özyazıcı, Yard. Doç. Dr. Mesut Arıcı, Doç. Dr. Sinem Yaprak Karavana, Doç. Dr. Evren Homan Gökçe, Doç. Dr. Emel Öykü Çetin Uyanıkgil, Doç. Dr. İpek Eroğlu
Learning Outcomes
1To comprehend the structure of colloidal dispersions and know how to elevate the stability, recognize the degradation characteristics.
2To be able to define the viscosity, to understand the measurement methods and to be able to list the substances used to increase viscosity
3To comprehend the emulsion forming theories, to be able to explain the preparation techniques in theoretical level, and be able to prepare them, to be able to evaluate the rheological behavior and stability of emulsions, to be able to define different types of emulsions and be able to prepare them 4- To be able to define the liquid crystals and be able to explain the formation mechanism
4To be able to define the liquid crystals and be able to explain the formation mechanism
5To be able to define liniment structure, be able to explain the preparation techniques and to be able to prepare liniments
Mode of Delivery
Face to Face
Prerequisites and co-requisities
None
Recommended Optional Programme Components
To attend the final exam, students have to be successful in the laboratory practice
Course Contents
Definition of Two-phased Systems and Colloidal Systems, the Properties of the Colloidal Systems, Preparation Techniques and Stability, Viscosity, Viscosity Measurement Methods, Viscosity Enhancers, Properties of the Dispersed Phase, Definition of Suspensions, Preparation and Properties, Definition of Emulsions, Surface Tension, Emulgators and their Classification, Liquid Crystalls, Triangle-phase-diagram, Emulsion Formation Theories, Emulsion Preparation Methods, Properties of Emulsions, Rheology, Multiple Emulsions, Micro-emulsions, Liniments, Definition of Ointments: Ointment Bases, Stability, Preparation and Packaging, The Factors Affecting Permeation and Penetration Through Skin, Penetration Enhancers, In vitro and In vivo Techniques used in Measurement of Absorption, Types of Ointments, Pastes, Soap, Definition of Suppositories and Preparation, the Tests of Suppositories, Definition of Ovules and preparation, Other pharmaceutical two-phased products, pediatric and geriatric dosage forms, Compounding
Weekly Detailed Course Contents
WeekTheoreticalPracticeLaboratory
1Definition of Two-phased Systems and Colloidal Systems, the Properties of the Colloidal Systems, Preparation Techniques and StabilityIntroduction, Reading and searching papers
2Viscosity, Viscosity Measurement Methods, Viscosity Enhancers Reading and searching papers
3Properties of the Dispersed Phase, Definition of Suspensions, Preparation and PropertiesPreparation of suspensions with menthol, suspensions with chloralhydrate, suspensions with sodium citrate, suspensions with magnesium hydroxide, suspensions with phenobarbital sodique
4Definition of Emulsions, Surface Tension, Emulgators and their ClassificationReading and searching papers
5Liquid Crystalls, Triangle-phase-diagram, Emulsion Formation TheoriesReading and searching papers
6Emulsion Preparation Methods, Properties of EmulsionsPreparation of emulsions with natural and synthetic emulgators
7Rheology, Multiple Emulsions, Micro-emulsionsReading and searching papers
8Liniments, Definition of Ointments: Ointment BasesPreparation of Liniments
9Stability, Preparation and PackagingPreparation of ointment with minium, ointment with methylene blue, ointment withrivanol, ointment with anesthesine
10The Factors Affecting Permeation and Penetration Through Skin, Penetration EnhancersReading and searching papers
11In vitro and In vivo Techniques used in Measurement of Absorption, Types of Ointments, Pastes, SoapPreparation of cold cream according to USP, Preparation of paste with zinc oxide, Lasser’s Psoriasis paste,
12MIDTERM EXAM
13Definition of Suppositories and Preparation, the Tests of SuppositoriesPreparation of glycerine suppositories, imhausen suppositories
14Definition of Ovules and preparation, Other pharmaceutical two-phased productsPreparation of imhausen ovule and ichtammol ovule
15Pediatric and geriatric dosage forms, CompoundingReading and searching papers
16FINAL EXAM
Recommended or Required Reading
1. Dermatological and Transdermal Formulations (Drugs and the Pharmaceutical Sciences), Kenneth A. Walters, Feb 20, 2002 2. Drug Permeation Enhancement (Drugs and the Pharmaceutical Sciences), Hsieh, Sep 17, 1993 3. Encyclopedia of pharmaceutical technology volume 1-5 4. European Pharmacopoeia 6.0, Council of Europe, Jul 23, 2007 5. Percutaneous Absorption: Drugs, Cosmetics, Mechanisms, Methods, Fourth Edition (Drugs and the Pharmaceutical Sciences), Robert L. Bronaugh, Howard I. Maibach, Jul 25, 2005 6. Surfactants and Polymers in Drug Delivery (Drugs and the Pharmaceutical Sciences) by Martin Malmsten (Hardcover - Jul 22, 2002 7. The Complete Drug Reference, 1992, United States Pharmacopeial Convention Inc. Permission granted, Consumer Reports Books 8. Topical Drug Delivery Formulations (Drugs and the Pharmaceutical Sciences), Osborne, Michael J. Rathbone, Michael S. Roberts, and Jonathan Hadgraft, Nov 7, 2002 9. Transdermal Drug Delivery Systems: Revised And Expanded (Drugs and the Pharmaceutical Sciences), Jonathan Hadgraft, Oct 29, 2002 10. Suppositories by Loyd V. Allen, Dennis B. Worthen, Bill Mink, Nov 20, 2007 11. Aerosol Technology: Properties, Behavior, and Measurement of Airborne Particles (Wiley-Interscience), William C. Hinds, Jan. 19, 1999 12. Rheology Essentials of Cosmetic and Food Emulsions (Springer Laboratory), Rüdiger Brummer, Sep 29, 2005 13. Poucher's Perfumes, Cosmetics and Soaps: Volume 2 The Production, Manufacture and Application of Perfumes (Poucher's Perfumes, Cosmetics, and Soaps), W. A. Poucher, Oct 31, 1992 14. Pharmaceutical Emulsions and Suspensions: Second Edition, Revised and Expanded (Drugs and the Pharmaceutical Sciences), Francoise Nielloud, Feb. 25, 2000 15. Steril pharmaceutical manufacturing applicatons for the 1990's, volume 1-2, M. J. Groves, W. P. Olson, M. H. Anisfeld 16. Microbial Contamination Control in the Pharmaceutical Industry (Drugs and the Pharmaceutical Sciences), Luis Jimenez, Aug 30, 2004 17. Farmasötik Teknoloji, Temel konular ve dozaj şekilleri, A. Z. Gürsoy, Kontrollü Salım Sistemleri Derneği, 2004 18. Kozmetik Bilimi, Y. Yazan, Nobel Tıp Kitabevleri, 2004 19. Modern Farmasötik Teknoloji, F. Acartürk, İ. Ağabeyoğlu, N. Çelebi, T. Değim, Z. Değim, T. Doğanay, S. Takka, F. Tırnaksız, Türk Eczacıları Birliği Eczacılık Akademisi Yayını, 2006
Planned Learning Activities and Teaching Methods
Activities are given in detail in the section of "Assessment Methods and Criteria" and "Workload Calculation"
Assessment Methods and Criteria
Term (or Year) Learning ActivitiesQuantityWeight
SUM0
End Of Term (or Year) Learning ActivitiesQuantityWeight
SUM0
SUM0
Language of Instruction
Turkish
Work Placement(s)
None
Workload Calculation
ActivitiesNumberTime (hours)Total Work Load (hours)
Midterm Examination11.51.5
Final Examination12.52.5
Attending Lectures14342
Practice19119
Laboratory10330
Individual Study for Mid term Examination13030
Individual Study for Final Examination14040
TOTAL WORKLOAD (hours)165.0
Contribution of Learning Outcomes to Programme Outcomes
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* Contribution Level : 1 Very low 2 Low 3 Medium 4 High 5 Very High
 
Ege University, Bornova - İzmir / TURKEY • Phone: +90 232 311 10 10 • e-mail: intrec@mail.ege.edu.tr