Description of Individual Course Units
Course Unit CodeCourse Unit TitleType of Course UnitYear of StudySemesterNumber of ECTS Credits
300001062015BIOPHYSICSCompulsory114
Level of Course Unit
First Cycle and Second Cycle
Objectives of the Course
To investigate biological structures and mechanisms under the light of physics science, to benefit from laws of physics for diagnosis and treatment of diseases.
Name of Lecturer(s)
Assoc. Prof. Dr. Erdal Binboğa
Learning Outcomes
1To recognize statics, dynamics, and kinematics
2To interpret concepts of energy, work, and power
3To interpret plasticity and elasticity topics
4To evaluate laws of thermodynamics
5To apply laws of thermodynamics to metabolic events
6To interpret concepts of hydrostatics and hydrodynamics
7To explain basic notions of electricity
8To understand and state biopotentials
9To recognize molecular bonds and explain molecular interactions
10To recognize biological membranes and interpret them biophysically
11To understand terms of diffusion, ultrafiltration, and hemodialysis
12 To interpret and discuss acid-base equilibria in body fluids
13To explain transport systems and molecular pumps
14To understand radiation, be able to discuss biological effects of it and protection from it
Mode of Delivery
Face to Face
Prerequisites and co-requisities
None
Recommended Optional Programme Components
None
Course Contents
After an introduction to mechanics, thermodynamics and electricity which are basic topics of physics, their applications on biological srtructures will be discussed with an aim of investigating biological events under the light of these basics. Molecular bonds and interactions will be discussed and biological membranes will be biophysically established. Body fluids will be widely examined, acid-base equilibria in these fluids and mechanisms that maintain this equilibria will be discussed. An introduction to radiation physics involving the biological effects of radiation will be provided at last and protection from radiation will be explained.
Weekly Detailed Course Contents
WeekTheoreticalPracticeLaboratory
1Mechanical magnitudes Statics: 1st and 3rd laws of Newton Dynamics: 2nd law of Newton Kinematics: Linear and angular motions
2Energy, work, and power: Gravitational and elastic potential energy, kinetic energy Other types of energy and their units Law of conservation of energy
3Examples to energy problems related to biological systems Concepts of plasticity and elasticity Stress, strain, and elasticity modulus
4Laws of thermodynamics Enthalpy, Hess’s law, entropy, free energy, spontaneousity, coupled reactions Free energy change of electron transfer: redox potentials, standard potentials, biochemical redox reactions, mechanism of oxidative phosphorylation
5Stages of metabolism, energy production from glucose, anaerobic and aerobic pathways, conversion of oxidation energy to energy of ATP, reactions of electron chain transport
6Hydrostatic pressure: manometers, blood pressure, pressure in fluids Hydrodynamics: flow rate, volume flow, pressure, and kinetic energy of fluids; Bernoulli’s principle Newtonian and non-Newtonian fluids, Poiseuille’s law Total resistance of systemic blood circulation, laminary and turbulent flow regimes
7Midterm Exam
8Electrical current and resistance, Ohm’s law, electromotive force and electrical circuits, resistive circuits, Kirchoff’s laws, potentiometer circuit, Wheatstone bridge circuit Types of electrical current and effects of electrical current to live tissues Electronics: alternative current in capacitors and inductors Transducers: biosensors, absorption spectrophotometer Capacitors in electrical circuits
9Magnetic field: Faraday’s law, magnetic flowmeter Diamagnetic, paramagnetic, and ferromagnetic materials Paramagnetic oxygen analyser Biopotentials: basic concepts, Nerst equation, resting potential, action potential, membrane conductance Clinically important biopotentials
10Molecular bonds: electrovalance and ionic bond, covalance, coordinated bond Weak interactions: van der Waals forces, ion-dipol and dipol-dipol attractions, hydrogen bond, London dispersion forces, repelling forces, quantitative approach to interactions
11Biological membranes: lipid bilayers Models of biological membranes: mobilities of lipids and proteins Asymmetric structure of biological membranes (protein asymmetry and lipid class asymmetry)
12Compartments of body fluids: determination of fluid compartments by principles of dilution, colligative properties of solutions: osmotic pressure Diffusion at membranes, ultrafiltration, hemodialysis Dialyser: clearance, dialysence
13Acid-base equilibria in body fluids: definition of pH, tampon solutions, physiological mechanisms that keep H+ concentration stable
14Transport systems and usage of metabolic energy in active transport: diffusion, active and passive transports Molecular pumps and exchangers: sodium/potassium and calcium pumps Active transport of glucose and amino acids, active transport systems in bacteria, pharmacological agents which influence ion permeability of biological membranes
15Classification of radiation: ionizing and non-ionizing radiation, radioactivity and particle radiation, artificial radioactivity Sources of radiation Nuclear decay: physical, biological, and effective half-lives, specifical activity Amount and dose of radiation, dose units Important radionuclides for human health and environment
16Final Exam
Recommended or Required Reading
Planned Learning Activities and Teaching Methods
Activities are given in detail in the section of "Assessment Methods and Criteria" and "Workload Calculation"
Assessment Methods and Criteria
Term (or Year) Learning ActivitiesQuantityWeight
Midterm Examination1100
SUM100
End Of Term (or Year) Learning ActivitiesQuantityWeight
Final Sınavı1100
SUM100
Term (or Year) Learning Activities40
End Of Term (or Year) Learning Activities60
SUM100
Language of Instruction
Turkish
Work Placement(s)
None
Workload Calculation
ActivitiesNumberTime (hours)Total Work Load (hours)
Midterm Examination111
Final Examination111
Attending Lectures14342
Self Study14114
Individual Study for Mid term Examination11515
Individual Study for Final Examination13333
Reading14114
TOTAL WORKLOAD (hours)120
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* Contribution Level : 1 Very low 2 Low 3 Medium 4 High 5 Very High
 
Ege University, Bornova - İzmir / TURKEY • Phone: +90 232 311 10 10 • e-mail: intrec@mail.ege.edu.tr