Description of Individual Course Units
Course Unit CodeCourse Unit TitleType of Course UnitYear of StudySemesterNumber of ECTS Credits
300004732017PHARMACEUTICAL TOXICOLOGY-ICompulsory474
Level of Course Unit
First Cycle and Second Cycle
Objectives of the Course
The first four weeks are devoted to complete specific toxic effects of chemicals namely mutagenesis, carcinogenesis, teratogenesis, and lastly, mechanisms, outcomes and treatment of acute poisonings. The aim of the course in the next six weeks is to teach the clinical drug-associated toxicities both at therapeutic and excess dose in a systematic manner; non-steroidal antiinflammatory drugs, chemotherapeutics, antibiotics, proton pump inhibitors and hematological drugs. The last four weeks are devoted to the comprehensive toxicology of the drugs used in three major clinical fields; cardiovascular system, autoimmune diseases and central nervous system.
Name of Lecturer(s)
Prof. Dr.Ferzan Lermioğlu Erciyas, Prof. Dr.Hilmi Orhan, Prof. Dr.Hande Gürer Orhan, Yard. Doç. Dr. Sumru Sözer Karadağlı
Learning Outcomes
1To be able to explain the basic principles of toxicology
2To be able to perform toxicological risk assessment of chemicals and safety assessment of consumer products
3Demonstrate an understanding of the processes involved in absorption, distribution, metabolism and excretion of toxicants
4Comprehensive understandings of target organ toxicity, mechanisms through chemical toxicants affect the structure and function of various organs
Mode of Delivery
Face to Face
Prerequisites and co-requisities
None
Recommended Optional Programme Components
None
Course Contents
Mutagenicity, carcinogenicity, teratogenicity, the general principles of treatment of acute poisonings, frequently encountered drug poisoning, Toxicity of metals, organic solvents, food and drug additives, pesticides, natural toxins and household products, drug abuse and air pollution.
Weekly Detailed Course Contents
WeekTheoreticalPracticeLaboratory
0Genetic Toxicology • What is the mutagenicity? • Classification of genotoxic effects • Analysis of genotoxic effect • DNA repair mechanisms•Toxicological analysis methods •Isolation of poisons •Chromatographic analysis •Spectrophotometric analysis
1Chemical Carcinogenesis • Basic concepts and nomenclature of tumors • Classification of chemical carcinogens • Steps of chemical carcinogenicityDetection of volatile poisons microdiffusion technique
2Teratogenesis • Basics and terms of teratogenicity • Stages of pregnancy regarding neonatal exposure • Teratogenic compounds/drugs Analysis of preservatives in milk
3General principles of treatment of acute poisonings -I 1. Decontamination 2. Reduce or prevent absorption 3. Acceleration of excretion of absorbed substanceExtraction of biological samples and identify the drugs commonly cause poisoning
4General principles of treatment of acute poisonings • General and specific methods of treatment 3. Systemic antidote treatment 4. Symptomatic and supporting treatment application Qualitative and quantitative analysis of the drugs commonly cause poisoning
5Toxicology of non-steroidal anti-inflammatory drugs-IQualitative and quantitative analysis of the drugs commonly cause poisoning
6Toxicology of non-steroidal anti-inflammatory drugs-IIQuantitative spectrophotometric analysis of biological liquids salicylate
7Toxicology of chemotherapeuticsAnalysis of metalic poisons
8Toxicology of proton pump inhibitorsQuantitative spectrophotometric analysis of nitrite in water and meat products
9Toxicology of hematological drugsQuantitative spectrophotometric analysis of biological liquids methanol
10Toxicology of antibiotics
11Toxicology of cardiovascular system drugs-I
12Toxicology of autoimmune system drugs
13Toxicology of central nervous system drugs
Recommended or Required Reading
1. Klaassen CD. Casarett and Doull’s Toxicology. 5th Edition, McGraw-Hill (2001). 2. Ellenhorn MJ. Ellenhorn’s Medical Toxicology, Diagnosis and Treatment of Human Poisoning. 2nd edition, Williams & Wilkins, Baltimore (1997). 3. Haddad LM, Winchester JF. Clinical Management of Poisoning and Drug Overdose. W.B. Saunders Company, Philadelphia (1983). 4. Fenton JJ. Toxicology; A Case-Oriented Approach. Informa Healthcare USA, New York (2008). 5. Ballantyne B, Marrs T, Turner P. General and Applied Toxicology, Vol. 2. New York, The Macmillan Press, (1993). 6. Hayes AW. Principles and Methods of Toxicology. 4th Edition, Taylor and Francis Inc. (2001). 7. Timbrell JA. Principles of Biochemical Toxicology, 3rd edition, London: Taylor & Francis (2002). 8. Pratt WB, Taylor P. Principles of Drug Action: The Basis of Pharmacology.3rd edition (1990) 9. Niesink RJM, de Vries J, Hollinger MA, Toxicology: Principles and Applications, Boca Raton, CRC Press, 1996.
Planned Learning Activities and Teaching Methods
Assessment Methods and Criteria
Term (or Year) Learning ActivitiesQuantityWeight
SUM0
End Of Term (or Year) Learning ActivitiesQuantityWeight
SUM0
SUM0
Language of Instruction
Turkish
Work Placement(s)
None
Workload Calculation
ActivitiesNumberTime (hours)Total Work Load (hours)
Midterm Examination111
Final Examination122
Attending Lectures14228
Practice10330
Self Study14228
Individual Study for Mid term Examination3618
Individual Study for Final Examination4624
Laboratory Examination133
TOTAL WORKLOAD (hours)134
Contribution of Learning Outcomes to Programme Outcomes
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LO1554355554353355434335
LO2554354554353355434325
LO3554345544453455434325
LO4554345544453455434325
* Contribution Level : 1 Very low 2 Low 3 Medium 4 High 5 Very High
 
Ege University, Bornova - İzmir / TURKEY • Phone: +90 232 311 10 10 • e-mail: intrec@mail.ege.edu.tr