Description of Individual Course Units
Course Unit CodeCourse Unit TitleType of Course UnitYear of StudySemesterNumber of ECTS Credits
300004742017PHARMACEUTICAL TOXICOLOGY-IICompulsory484
Level of Course Unit
First Cycle and Second Cycle
Language of Instruction
Turkish
Objectives of the Course
The first four weeks are devoted to complete specific toxic effects of chemicals namely mutagenesis, carcinogenesis, teratogenesis, and lastly, mechanisms, outcomes and treatment of acute poisonings. The aim of the course in the next six weeks is to teach the clinical drug-associated toxicities both at therapeutic and excess dose in a systematic manner; non-steroidal antiinflammatory drugs, chemotherapeutics, antibiotics, proton pump inhibitors and hematological drugs. The last four weeks are devoted to the comprehensive toxicology of the drugs used in three major clinical fields; cardiovascular system, autoimmune diseases and central nervous system.
Name of Lecturer(s)
Prof. Dr.Ferzan Lermioğlu Erciyas, Prof. Dr.Hilmi Orhan, Prof. Dr.Hande Gürer Orhan, Yard. Doç. Dr. Sumru Sözer Karadağlı
Learning Outcomes
1To have basic information to make assessment in teratojenicity, chemical carcinogenesis and genetic toxicology
2Develop analytical thinking and problem-solving in toxicity cases occurred by individual drugs or drug -drug interactions
3To be able to outline general principles of treatment of acute poisoning
4Demonstrate an understanding of the mechanisms underlying in toxicity induced by NSAIDs, chemotherapeutics, antibiotics, proton pump inhibitors, comprehensive toxicology of the drugs used in diseases of hematological system, cardiovascular system, central nervous system and drugs used in autoimmune disorders.
Mode of Delivery
Face to Face
Prerequisites and co-requisities
None
Recommended Optional Programme Components
None
Course Contents
Mutagenicity, carcinogenicity, teratogenicity, general principles of treatment of acute poisonings, frequently encountered drug poisonings, toxicity of NSAIDs, chemotherapeutics, antibiotics, proton pump inhibitors, comprehensive toxicology of drugs used in diseases with hematology, cardiovascular system, central nervous system and drugs used in autoimmune disoreders.
Weekly Detailed Course Contents
WeekTheoreticalPracticeLaboratory
1Genetic Toxicology • What is the mutagenicity? • Classification of genotoxic effects • Analysis of genotoxic effect • DNA repair mechanisms•Toxicological analysis methods •Isolation of poisons •Chromatographic analysis •Spectrophotometric analysis
2Chemical Carcinogenesis • Basic concepts and nomenclature of tumors • Classification of chemical carcinogens • Steps of chemical carcinogenicityDetection of volatile poisons microdiffusion technique
3Teratogenesis • Basics and terms of teratogenicity • Stages of pregnancy regarding neonatal exposure • Teratogenic compounds/drugs Analysis of preservatives in milk
4General principles of treatment of acute poisonings -I 1. Decontamination 2. Reduce or prevent absorption 3. Acceleration of excretion of absorbed substanceExtraction of biological samples and identify the drugs commonly cause poisoning
5General principles of treatment of acute poisonings • General and specific methods of treatment 3. Systemic antidote treatment 4. Symptomatic and supporting treatment application Qualitative and quantitative analysis of the drugs commonly cause poisoning
6Toxicology of non-steroidal anti-inflammatory drugs-IQualitative and quantitative analysis of the drugs commonly cause poisoning
7Toxicology of non-steroidal anti-inflammatory drugs-IIQuantitative spectrophotometric analysis of biological liquids salicylate
8Toxicology of chemotherapeuticsAnalysis of metalic poisons
9Toxicology of proton pump inhibitorsQuantitative spectrophotometric analysis of nitrite in water and meat products
10Toxicology of hematological drugsQuantitative spectrophotometric analysis of biological liquids methanol
11Toxicology of antibiotics
12Toxicology of cardiovascular system drugs-I
13Toxicology of autoimmune system drugs
14Toxicology of central nervous system drugs
Recommended or Required Reading
1. Klaassen CD. Casarett and Doull’s Toxicology. 8th Edition, McGraw-Hill (2018). 2. Ellenhorn MJ. Ellenhorn’s Medical Toxicology, Diagnosis and Treatment of Human Poisoning. 2nd edition, Williams & Wilkins, Baltimore (1997). 3. Haddad LM, Winchester JF. Clinical Management of Poisoning and Drug Overdose. W.B. Saunders Company, Philadelphia (1983). 4. Fenton JJ. Toxicology; A Case-Oriented Approach. Informa Healthcare USA, New York (2008). 5. Ballantyne B, Marrs T, Turner P. General and Applied Toxicology, Vol. 2. New York, The Macmillan Press, (1993). 6. Hayes AW. Principles and Methods of Toxicology. 4th Edition, Taylor and Francis Inc. (2001). 7. Timbrell JA. Principles of Biochemical Toxicology, 3rd edition, London: Taylor & Francis (2002). 8. Pratt WB, Taylor P. Principles of Drug Action: The Basis of Pharmacology.3rd edition (1990) 9. Niesink RJM, de Vries J, Hollinger MA, Toxicology: Principles and Applications, Boca Raton, CRC Press, 1996.
Planned Learning Activities and Teaching Methods
Assessment Methods and Criteria
Term (or Year) Learning ActivitiesQuantityWeight
Midterm Examination1100
SUM100
End Of Term (or Year) Learning ActivitiesQuantityWeight
Final Sınavı1100
SUM100
Term (or Year) Learning Activities40
End Of Term (or Year) Learning Activities60
SUM100
Work Placement(s)
None
Workload Calculation
ActivitiesNumberTime (hours)Total Work Load (hours)
Midterm Examination111
Final Examination122
Attending Lectures14228
Practice10330
Self Study14228
Individual Study for Mid term Examination3618
Individual Study for Final Examination4624
Laboratory Examination133
TOTAL WORKLOAD (hours)134
Contribution of Learning Outcomes to Programme Outcomes
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LO1555455554352452324224
LO2555455555354552334225
LO3555455554353452224224
LO4555455555354552355225
* Contribution Level : 1 Very low 2 Low 3 Medium 4 High 5 Very High
 
Ege University, Bornova - İzmir / TURKEY • Phone: +90 232 311 10 10 • e-mail: intrec@mail.ege.edu.tr