Description of Individual Course Units
Course Unit CodeCourse Unit TitleType of Course UnitYear of StudySemesterNumber of ECTS Credits
10420201E11614MOLECULAR BIOLOGYCompulsory245
Level of Course Unit
First Cycle
Objectives of the Course
The course introduces the students to the different types of chemical bonds, the common characteristics of biomolecules and biologic events, the importance of the relation between structure-function in four types of biomolecules. The course is designed to provide an overview of nucleic acids, proteins, carbohydrates and lipids as the biomolecules involved in a number of biological functions and industrial applications. In addition, some selected biological events, such as the control of cell cycle and cancer are described.
Name of Lecturer(s)
Prof.Dr. Sabire KARAÇALI, Assoc. Prof. Dr. Remziye DEVECİ, Assoc. Prof. Dr. Cemal ÜN, Assoc. Prof. Dr. N. Ülkü KARABAY YAVAŞOĞLU, Assist. Prof. Dr. Melike Bor
Learning Outcomes
1Understanding the importance of biological bonds in molecular interactions within the biomolecules
2Describing the molecular structures, biologic functions, molecular mechanisms of synthesis and processing of biomolecules
3Describing the key enzymes and the concepts involved in the synthesis of biopolymers
4Understanding the gene structure and transcriptional control of gene expression in procaryotes
5Understanding the gene structure and transcriptional control of gene expression in eucaryotes
6Discussing the importance of post-translational modification mechanisms
7Describing the molecular mechanisms of special proteins such as; transporter, signal transduction, motor and immunoglobin proteins
8Discussing importance of microheterogenity in carbohydrates
9Describing the special biological events
Mode of Delivery
Face to Face
Prerequisites and co-requisities
None
Recommended Optional Programme Components
None
Course Contents
Biomolecules and Chemical Bonds, Classification of Biomolecules, DNA Synthesis (Replication), Mutations and DNA Repair, RNA Synthesis (Transcription), Protein Synthesis (Translation), Gene Regulation, Proteins, Carbohydrates
Weekly Detailed Course Contents
WeekTheoreticalPracticeLaboratory
1Biomolecules and chemical bonds
2Classification of Biomolecules: Nucleic acids, Amino acids, Carbohydrates, Fatty acids
3DNA Synthesis (Replication) I (DNA polymerases of procaryotics and eucaryotics)
4DNA Synthesis (Replication) II (DNA replication of procaryotes, comparing DNA replication in procaryotes and eucaryotes)
5Mutations and DNA repair
6RNA Synthesis (Transcription)
7Protein Synthesis (Translation) I
8Midterm
9Protein Synthesis (Translation) II (Mechanism of Protein Synthesis in ribosomes, Post-Translation Modifications)
10Regulation of Gene Expression I: (Procaryotic and Eucaryotic Gene Regulation)
11Regulation of Gene Expression II: (Control of RNA Process)
12Proteins I: (Structure of proteins, Functions of proteins)
13Proteins II: (Motor and Signal Transduction)
14Proteins III: (Immunoglobulins)
15Carbohydrates: (Glycoconjugates, Importance of Microheterogenity)
16Final Exam
Recommended or Required Reading
Molekuler Biyoloji Teksiri, Karaçalı S., Ege Universitesi Fen Fakültesi Teksirler Serisi, 2004. Molecular Cell Biology, Darnell J., Lodish H. and Baltimore D., second edition, Scientific American Boks, 1990. Molecular Biology of the Cell, Alberts B., Johnson A., Lewis J., Raff M., Roberts K. and Walter P., Garland Science, 2002. Essentials of Molecular Biology, Malacinski G.M. and Freifelder D., Third Edition, Jones and Bartlett Publishers, 1998. R.F. Weaver. Molecular Biology, Second Edition, McGraw Hill, 2003. B.Alberts, A. Johnson, J. Lewis, M. Raff, K. Roberts, P. Walter. Molecular Biology of the Cell, FifthEdition, Garland Science, 2008.
Planned Learning Activities and Teaching Methods
Activities are given in detail in the section of "Assessment Methods and Criteria" and "Workload Calculation"
Assessment Methods and Criteria
Term (or Year) Learning ActivitiesQuantityWeight
SUM0
End Of Term (or Year) Learning ActivitiesQuantityWeight
SUM0
SUM0
Language of Instruction
English
Work Placement(s)
None
Workload Calculation
ActivitiesNumberTime (hours)Total Work Load (hours)
Midterm Examination122
Final Examination122
Attending Lectures14228
Report Preparation4832
Seminar248
Self Study12336
Individual Study for Mid term Examination188
Individual Study for Final Examination188
Reading12224
TOTAL WORKLOAD (hours)148
Contribution of Learning Outcomes to Programme Outcomes
PO
1
PO
2
PO
3
PO
4
PO
5
PO
6
PO
7
PO
8
PO
9
PO
10
PO
11
PO
12
PO
13
PO
14
LO15555 555515555
LO215555555125555
LO315351555135211
LO4 155    5     
LO5 152    55    
LO62      5   53 
LO71     111 5555
LO85            5
LO95      5  3  5
* Contribution Level : 1 Very low 2 Low 3 Medium 4 High 5 Very High
 
Ege University, Bornova - İzmir / TURKEY • Phone: +90 232 311 10 10 • e-mail: intrec@mail.ege.edu.tr