Description of Individual Course Units
Course Unit CodeCourse Unit TitleType of Course UnitYear of StudySemesterNumber of ECTS Credits
10420201E11363GENETICS ICompulsory355
Level of Course Unit
First Cycle
Objectives of the Course
The aim of this course is to give the student an understanding of the basic concepts of genetics; the ability to relate the gene, genotype and phenotype; the ability to having analytical thinking, to generating experimental logic and to solving problems related to genetics; an understanding of Mendelian and Non-Mendelian genetics, models of inheritance, laws of probability, pedigree trees, sex determination, gene linkage, chromosomal mapping, extrachromosomal inheritance and chromosomal mutations and the ability to relating these topics.
Name of Lecturer(s)
Assoc. Prof. Dr. N.Ülkü KARABAY YAVAŞOĞLU
Learning Outcomes
1To be able to learn the basic concepts of genetics
2To be able to appreciate basic principles of heredity
3To be able to relate the approaches of different disciplines such as molecular biology, biochemistry, statistics with genetics
4To be able to relate the gene, genotype and phenotype
5To be able to apply the consepts of genetics to daily life
6To be able to examine the relationship between the concepts and experiments of genetics
7To be able to search genetics databases and evaluate informations from multiple sources and viewpoints by means of oral and written manners
8To be able to relate between experimental logic, analytical thinking, quantitative analysis and problem solving.
Mode of Delivery
Face to Face
Prerequisites and co-requisities
None
Recommended Optional Programme Components
None
Course Contents
Introduction to Genetics, Cell Cycle, Cell Division, Mendelian Genetics, Probability, Pedigri, Extentions of Mendelian Genetics: Complete, incomplete Dominance, Multiple alleles, incompatibilty alleles,lethal alleles, Gene interactions, X-linked inheritance, Sex determination and sex chromosomes, Linkage in eukaryotes, Mitotic recombination,Sister chromatid exchanges, tetrad analysis, Recombination in Bacteria and bacteriophage and mapping, Extrachromosomal inheritance, Chromosomal mutations
Weekly Detailed Course Contents
WeekTheoreticalPracticeLaboratory
1Introduction to Genetics: History of the Genetics, The Founding of Modern Biology, Basic concepts of geneticsMitoz bölünmenin incelenmesi (Soğan kök ucunda)Microscope observations: Mitosis in the onion root tip
2Interphase and Cell Cycle, Cell divisions:Cell cycle control molecules, control points, mitosis and meiosis, gametogenesis Hayvan kemik iliği ve insan periferik kan preparatlarında metafaz kromozomlarının incelenmesiMicroscope observations: Metaphase chromosomes from animal bone marrow and human lymphocytes
3Mendelian Genetics: Mendel Laws, monohybrid and dihybrid crosses, reciprocal, test crosses, phenotype and genotype ratiosGametogenezin (spermatogenez ve oogenez) incelenmesi (ovaryum ve testis preparatları) ve problemlerinin çözümüMicroscope observation: Gametogenesis from testes and ovary Problem solving
4Probability: multiplication and addition law, conditional probability, binomial theorem, khi square test, pedigree treesMonohibrit çaprazlamalar (Test-kros, geri çaprazlama)monohybrid cross (test and back crosses)
5Extentions of Mendelian Genetics: Complete, incomplete Dominance, Multiple alleles, incompatibilty alleles,lethal alleles, pleitropyPedigri analizi ve problemlerPedigree analysis and problem solving
6Gene interactions:Discontinious variation, Epistatic and nonepistatic gene interactions, complementation analysisAllelik ilişkiler (Dominant-resesif, kodominant, multiple ve letal alleller)Allelik interactions (dominance, recessive, codominance, multiple, lethal)
7X-linked inheritance: In human and Drosophila, Holandric genes, sex limited inheritance, genotype-environment interactions, penetrance and expressivity, gene expression, genetic , genomic imprintingİnsanlarda kan grubu tayini ve problem çözümü ABO blood types in human and problem solving
8Midterm
9Sex determination and sex chromosomes: Sex dimorphism and life cycles, model organisms, X and Y chromosomes, dosage compensation, Barr body, Lyon hypothesis, Dihibrit çaprazlamalar, modifiye dihibrit oranlarıDihybrid crosses and modified dihybrid ratios
10Linkage in eukaryotes, crossover, chiasma frequency, crossover and chromosome mapping, coupling and repulsion, three point mapping, interference X’ e bağlı kalıtım problemleriX-linked inheritance (problem solving)
11Mitotic recombination,Sister chromatid exchanges, tetrad analysis, Mapping in humans, syntheny test Ökaryotlarda linkage, üç noktalı gen haritalaması, interferens ve uygunluk katsayısı hesaplamaları, F2 verilerinden bağlantı hesaplanmasıLinkage in eukaryotes, three point mapping, interference (problem solving)
12Recombination in Bacteria and bacteriophage and mapping: Conjugation, Transformation, transductiıon Ascomycetes’ de tetrat analizi problemleri Tetrad analysis in Ascomycetes (problem solving)
13Extrachromosomal inheritance: organelle inheritance, endosymbiotic theory,Infection type inheritance, maternal effect Bakterilerde rekombinasyon ve haritalama problemleri Recombinationand mapping in Bacteria (problem solving)
14Chromosomal mutations: changes in chromosome number Kromozomal varyasyonlar Chromosomal variations
15Chromosomal mutations:changes in chromosom structure Laboratuar Sınavı Laboratory exam
16Final Exam
Recommended or Required Reading
TEXT BOOK: Klug,W.S., Cummings, M.R. and Spencer, C.A. “Genetik Kavramlar” Ç ed. Öner, C ve ark. Palme Yayıncılık, Ankara, 2009. OTHER REFERENCES: Tamarın,R. “Principles of Genetics”, Thirt Edition. Wm. C. Brown Publishers, 1991. Stansfield W.D., “Theory and Problems of Genetics”, Sc.edit.Schaum’s Outline Series,McGraw-Hill Book Compaany,New York, 1998.
Planned Learning Activities and Teaching Methods
Activities are given in detail in the section of "Assessment Methods and Criteria" and "Workload Calculation"
Assessment Methods and Criteria
Term (or Year) Learning ActivitiesQuantityWeight
SUM0
End Of Term (or Year) Learning ActivitiesQuantityWeight
SUM0
SUM0
Language of Instruction
English
Work Placement(s)
None
Workload Calculation
ActivitiesNumberTime (hours)Total Work Load (hours)
Midterm Examination122
Final Examination122
Attending Lectures15230
Laboratory15230
Problem Solving339
Report Preparation236
Report Presentation224
Self Study6212
Individual Study for Homework Problems236
Individual Study for Mid term Examination11212
Individual Study for Final Examination11212
Reading11222
TOTAL WORKLOAD (hours)147
Contribution of Learning Outcomes to Programme Outcomes
PO
1
PO
2
PO
3
PO
4
PO
5
PO
6
PO
7
PO
8
PO
9
PO
10
PO
11
PO
12
PO
13
PO
14
LO11        1    
LO2 1  1       1 
LO31 1           
LO4        1111  
LO5  1 1         
LO6   1 11       
LO7111           
LO8              
* Contribution Level : 1 Very low 2 Low 3 Medium 4 High 5 Very High
 
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