Description of Individual Course Units
Course Unit CodeCourse Unit TitleType of Course UnitYear of StudySemesterNumber of ECTS Credits
404002082000ORGANIC CHEMISTRY IICompulsory249
Level of Course Unit
First Cycle
Objectives of the Course
The primary aims of this course is to appreciate the reactions of alcohols, substitution, elimination, esterification, and oxidation, and know how formation of derivatives can modify their reactivity in substitution and elimination reactions. Know reactions for the formation of ethers, including epoxides and other cyclic ethers. Understand the bonding in 1,3-dienes and their reactions in electrophilic addition and the Diels Alder reaction. To develop an understanding of the nature of aromaticity, basic mechanistic and reactivity principles and common reactions of aromatic and heteroaromatic systems.
Name of Lecturer(s)
Prof. Dr. Özgen ÇALIŞKAN, Prof.Dr.Demet ASTLEY, Prof. Dr. Stephen T. ASTLEY, Assoc. Prof. Dr. Yurdanur AKGÜL, Assoc. Prof. Dr. Tamer KARAYILDIRIM, Assoc. Prof. Dr. Yeşim GÜL SALMAN
Learning Outcomes
1To design basic synthetic applications about reactions and preparation of alcohols, eters, unsaturated conjugated systems, aromathic compounds and and to interpret the results of these subjects.
2To design basic synthetic applications about reactions and preparation of item 1.
3To be able to interpret the reaction of alcohols and eters
4To be able to interpret the reaction of conjugated unsaturated systems and aromatic compounds
Mode of Delivery
Face to Face
Prerequisites and co-requisities
None
Recommended Optional Programme Components
None
Course Contents
Alcohols and ethers;- Draw the mechanism and predict the products of substitution, elimination, and redox reactions of alcohols, ethers, and epoxides, including the Williamson ether synthesis, dehydration reactions catalyzed by acids and other reagents, conversions of alcohols to alkyl halides using hydrohalogens and other reagents, tosylate formation. Acid-catalyzed decomposition of ethers, and the stereochemical ramifications of epoxide-opening reactions in the presence and absence of acid catalysts, Chemistry of Thiols/Sulfides, Nomenclature of Thiols/Sulfides, Synthesis of Thiols/Sulfides, Reactions of Thiols to Disulfides, Oxidations of alcohols to form aldehydes, carboxylic acids, and ketones;Organic oxidation and reduction reactions, Organometalic compounds and their reactions;Conjugated unsaturated systems;- Dienes, The stability of the Allylic Carbocations, Rules of resonance,The stability of the conjugated dienes and alkadienes, 1,4 Addition, 1,2 Addition, Thermodynamic vs. Kinetic Control of Addition, Diels-Alder Reaction,Nomenclature of Aromatic Compounds, Hückel 4n + 2 Rule, Aromaticity within Polycyclic Molecules, ,Electrophilic Aromatic Substitution,- Bromination and Chlorination of Aromatics, Sulfonation and Nitration of Aromatics, Friedel-Crafts Alkylations, Friedel-Crafts Acylations, Identification of Electron Withdrawing Groups (EWG) and Electron Donating Groups (EDG), Reactivity Affects of EWGs and EDGs, Benzyne, Benzylic Oxidation, Benzylic Bromination, Nucleophilic Aromatic Substitution, Substitution reactions of Arendiazonium salts.
Weekly Detailed Course Contents
WeekTheoreticalPracticeLaboratory
1Structural features, physical, chemical properties and nomenclature of alcohols, Synthesis of Alcohols Recognize the laboratory equipment, laboratory safety, and laboratory rules
2Synthesis of Alcohols (cont.)Crystallization
3Reactions of alcohols (Dehydration of Alcohols, Oxidations of alcohols, Conversion of Alcohols into Alkyl Halides and mesylates and Tosylates, Oxidation of Alcohols, Alcohol’s Reaction with Trimethyl Silane)Distillation
4Chemistry of Ethers and Epoxides, nomenclature of Ethers and Epoxides, Synthesis of Ethers and Epoxides,Cleavage of Ethers and Epoxides under Acidic or Basic Conditions, Crown ethers. Chemistry of Thiols and Sulfides, Nomenclature of Thiols and Sulfides, Synthesis of Thiols/Sulfides, Oxidation of Thiols to Disulfides.Extraction
5Organic oxidation and reduction reactionsChromatography
6Conjugated dienes. Allylic Carbocations and radicals, resonance structures of allylic cations and radicals, the rules of resonances allylic substitution reactions. Synthesis of fumaric acid from maleic acid
7 Midterm Exam Synthesis of cyclohexene
8Electrophilic addition to conjugated dienes (1,2 and 1,4 additions, thermodinamic and kinetic controlled reactions), Diels-Alder reactionsOxidation of alcohols
9Aromatic Compounds; Aromaticity, Nomenclature of Aromatic Compounds Molecular Orbital Theory of Organic Compounds, Hückel 4n + 2 RuleSynthesis of aspirin
10Aromaticity within Polycyclic Molecules Aromatic and heterocyclic aromatic compoundsSynthesis of n-butyl bromide
11Electrophilic Aromatic Substitution: Mechanism, Substitution reactions, Halogenation, Nitration, Sulfonation, Friedel-Crafts alkylation, Friedel-Crafts acylation Substituent effects in substituted aromatic rings;
12Reactivity, Orientation and Synthetic applications Reactions of substituents and side chains of aromatic rings;
13Reduction of nitro groups, Diazotization, Oxidation of carbon side chains, Reactions of Alkylbenzene side chains Reduction of Aromatic compounds (Birch Reduction).
14Substitution reactions of Arendiazonium salts. Phenols, Aryl halides and Nucleophilic Aromatic Substitution Reactions, Benzyne, Benzylic Oxidation, Benzylic Brom
15Synthetic applications of Electrophilic Aromatic Substitution reactions
16Final Exam
Recommended or Required Reading
Course Book(s): “Organik Kimya” Craig FRYHLE, Graham SOLOMONS, Literatür Yayıncılık, ISBN: 978-975-843-187-8 “Organik Kimya-Yaşamın kalbi ”, Yılmaz YILDIRIR, Bilim Yayınları, ISBN: 978-975-556-070-0 Helper Book(s): “Organic Chemistry” Leroy G. WADE, ISBN: 978-0321768414
Planned Learning Activities and Teaching Methods
Activities are given in detail in the section of "Assessment Methods and Criteria" and "Workload Calculation"
Assessment Methods and Criteria
Term (or Year) Learning ActivitiesQuantityWeight
SUM0
End Of Term (or Year) Learning ActivitiesQuantityWeight
SUM0
SUM0
Language of Instruction
Turkish
Work Placement(s)
None
Workload Calculation
ActivitiesNumberTime (hours)Total Work Load (hours)
Midterm Examination122
Final Examination122
Attending Lectures14342
Experiment10440
Report Preparation10330
Self Study10330
Individual Study for Mid term Examination15555
Individual Study for Final Examination18080
TOTAL WORKLOAD (hours)281
Contribution of Learning Outcomes to Programme Outcomes
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LO14 3 5 4    5   3  5 4 
LO254 5     4   4   4   4
LO3553553     4     4  44
LO4553553     4     4  44
* Contribution Level : 1 Very low 2 Low 3 Medium 4 High 5 Very High
 
Ege University, Bornova - İzmir / TURKEY • Phone: +90 232 311 10 10 • e-mail: intrec@mail.ege.edu.tr