Description of Individual Course Units
Course Unit CodeCourse Unit TitleType of Course UnitYear of StudySemesterNumber of ECTS Credits
404004232001BIOPHYSICAL CHEMISTRYElective483
Level of Course Unit
First Cycle
Objectives of the Course
Basic biophysical chemistry is intended to help students to understand some important and necessary basic concepts of physical chemistry that related to biochemical process without using advanced mathematical knowledge and formulas.
Name of Lecturer(s)
Assoc. Prof. Dr. Nursel Acar Selçuki
Learning Outcomes
1To learn the definition and main concepts of biophysical chemistry
2To be able to comment on the results
3To be able to correlate the mathematical equations with the theoretical concepts
4To be able to compare the methods used in terms of their advantages/disadvantages
5To learn the terminology of biophysical chemistry
6To understand the principles of thermodynamics and its application to biochemistry
7To understand the principles of kinetics and its application to biochemistry
Mode of Delivery
Face to Face
Prerequisites and co-requisities
None
Recommended Optional Programme Components
None
Course Contents
Importance of pH in biochemical process, Effect of pH in metabolic reactions involving protons, Chemical thermodynamics, Thermodynamic standard states and standard functions, Chemical equilibrium and the coupling of reactions, The application of thermodynamics to biochemistry, The kinetics of chemical reactions, The kinetics of enzyme catalysed reactions
Weekly Detailed Course Contents
WeekTheoreticalPracticeLaboratory
1Solutions
2Acid and Bases
3pH in Biochemistry (Buffer properties of proteins, peptides and amino acids)
4pH in Biochemistry (pH dependent ionization of proteins, peptides and amino acids)
5pH in Biochemistry (Hemoglobin, Gibbs-Donnan Equilibrium)
6Thermodynamics-I (Laws of Thermodynamics)
7Thermodynamics-II (Thermodynamic Systems)
8Midterm Exam
9Biochemical Thermodynamic
10Chemical Equilibrium
11Kinetics of Chemical Reactions-I (Determination of reaction order, rate constant, half-life)
12Kinetics of Chemical Reactions-II (Rate and kinetic equations, 0., 1., 2. and pseudo 1. order reactions)
13Kinetics of Chemical Reactions-III (Collision Theory, Transition-State Theory, Activation Energy)
14Enzyme Kinetics-I (Enzymes, Enzyme Kinetics, Michaelis-Menten and Lineweaver-Burke equations)
15Enzyme Kinetics-II (Competitive, Noncompetitive and Uncompetitive inhibitions, enzyme catalysis, temperature and pH)
16Final Exam
Recommended or Required Reading
A. Altunata, T. Altunata, “Fizikokimya”, 2. Baskı, Ege Üniversitesi Yayınları No:160, (2006) K. E. von Holdes, W.C. Johnson, P.S. Ho, “Principles of Physical Biochemistry”, Prentice Hall, Inc., (1998) N. C. Price, R. A. Dwek, R. G. Ratcliffe, M.R. Wormold,”Principles and Problems in Physical Chemistry for Biochemist”, Oxford University Press, (2001) D.T. Haynie, “Biological Thermodynamics”, Cambridge University Press, (2001) P.Atkins and J.de Paula, “Physical Chemistry for the Life Sciences”, Oxford University Press, (2006)
Planned Learning Activities and Teaching Methods
Activities are given in detail in the section of "Assessment Methods and Criteria" and "Workload Calculation"
Assessment Methods and Criteria
Term (or Year) Learning ActivitiesQuantityWeight
SUM0
End Of Term (or Year) Learning ActivitiesQuantityWeight
SUM0
SUM0
Language of Instruction
Turkish
Work Placement(s)
None
Workload Calculation
ActivitiesNumberTime (hours)Total Work Load (hours)
Midterm Examination122
Final Examination122
Attending Lectures14228
Tutorial14228
Writing Paper717
Individual Study for Mid term Examination11010
Individual Study for Final Examination11515
Reading177
TOTAL WORKLOAD (hours)99
Contribution of Learning Outcomes to Programme Outcomes
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* Contribution Level : 1 Very low 2 Low 3 Medium 4 High 5 Very High
 
Ege University, Bornova - İzmir / TURKEY • Phone: +90 232 311 10 10 • e-mail: intrec@mail.ege.edu.tr