Description of Individual Course Units
Course Unit CodeCourse Unit TitleType of Course UnitYear of StudySemesterNumber of ECTS Credits
404004332001MEDICINAL CHEMISTRYElective483
Level of Course Unit
First Cycle
Objectives of the Course
The purpose of the course is to study basic chemical properties leading to drug activity and examine biological process in terms of qualitative and quantitative aspects; introducing the chemical structures and chemical and phsicochemical properties of the drug groups in course content; to associate those properties with pharmaceutic, pharmacokinetic and pharmacodynamic process.
Name of Lecturer(s)
Prof. Dr. Erçin ERCİYAS
Learning Outcomes
11. Being able to understand and interpret the chemical properties causing the pharmaceutical actvity and their relations with biological process.
25. To be able to understand the general chemical structure leading to a pharmacological response and predict the structure activity relationship.
36. Being able to understand and predict the drud-drug interactions by interrelating pharmacodynamic and pharmakokinetic concept with drugs’ chemical and physicochemical properties in biological systems.
47. Being able to predict the chemical structures and the possible incompatibilities of activemolecules and excipients and use this knowledge in formulatin
52. Being able to understand the relations between pharmacokinetic properties with chemical structures of the synthetic and semisynthetic molecules used as drug active compound
63. Being able to understand the relations between pharmacodynamic properties with chemical structures of the synthetic and semisynthetic molecules used as drug active compound and use this knowledge during the treatment.
74. Being able to evaluate the potentials of biological response of the molecules in terms of chemical structure and reactivity.
Mode of Delivery
Face to Face
Prerequisites and co-requisities
None
Recommended Optional Programme Components
None
Course Contents
The purpose of the course is to study basic chemical properties leading to drug activity and examine biological process in terms of qualitative and quantitative aspects; introducing the chemical structures and chemical and phsicochemical properties of the drug groups in course content; to associate those properties with pharmaceutic, pharmacokinetic and pharmacodynamic process.
Weekly Detailed Course Contents
WeekTheoreticalPracticeLaboratory
11. Introduction to Medicinal Chemistry 2. Methods for ıdentifying new lead compounds
23. New Drug Development Process 4.İlaç etkisinin oluşumuna kadar gerçekleşen ana işlemler 4.1.Pharmaceutical stage
3 4.2.Pharmacokinetic stage 4.2.1.Blood- brain barrier 4.2.2. Quantitative structure-activity relationship (QSAR) 4.2.2.1.History 4.2.2.2.Overton-Meyer Method
4 4.2.2.3. hydrophobic parameters 4.2.2.3.1. partition coefficient 4.2.2.3.2. Ferguson equation 4.2.2.3.3.Hansch Aromatic substituent constants 4.2.2.3.4.Rm
5 4.2.2.4.Electronic parameters 4.2.2.4.1.Hammet substituent constants 4.2.2.5.Steric parameters
6 4.2.2.6. Hansch Analysis 4.2.2.7. Topliss approach
7 4.2.2.8. The degree of ionization 4.2.2.9. The solubility of organic compounds
8Midterm exam
9 4.2.3. Bioisosterism 4.2.3.1. classical bioisosterism 4.2.3.1.non- classic bioisosterism
10 4.3.Pharmacodynamic phase 4.3.1.Reseptor 4.3.2.Types of intearction in drug-receptor binding
11 4.4.Prodrugs 4.4.1.Reasons for preparing pro-drug
12 4.4.2. Bioprecursor prodrugs 4.4.3. Carrier prodrugs
134.4.4.Salt forms of prodrug 4.4.5.Hard and Soft drugs
144.5. Metabolism 4.5.1.Importance of metabolism ın drug development studies
154.5.2.Phase I reactions- biotransformation 4.5.3. Phase I reactions -Kongugation
16Final Exam
Recommended or Required Reading
1.Farmasötik Kimya I Ders Notları (Medisinal Kimyaya Giriş), Prof. Dr. Erçin Erciyas, İzmir, 2010
Planned Learning Activities and Teaching Methods
Activities are given in detail in the section of "Assessment Methods and Criteria" and "Workload Calculation"
Assessment Methods and Criteria
Term (or Year) Learning ActivitiesQuantityWeight
SUM0
End Of Term (or Year) Learning ActivitiesQuantityWeight
SUM0
SUM0
Language of Instruction
Turkish
Work Placement(s)
None
Workload Calculation
ActivitiesNumberTime (hours)Total Work Load (hours)
Midterm Examination122
Final Examination122
Attending Lectures14228
Individual Study for Mid term Examination12020
Individual Study for Final Examination14040
TOTAL WORKLOAD (hours)92
Contribution of Learning Outcomes to Programme Outcomes
PO
1
PO
2
PO
3
PO
4
PO
5
PO
6
PO
7
PO
8
PO
9
PO
10
PO
11
PO
12
PO
13
PO
14
PO
15
PO
16
PO
17
PO
18
PO
19
PO
20
PO
21
PO
22
LO1          4 4         
LO2    5     4           
LO3    5     4           
LO4              5       
LO5 4        5           
LO6 4        4           
LO7            5         
* Contribution Level : 1 Very low 2 Low 3 Medium 4 High 5 Very High
 
Ege University, Bornova - İzmir / TURKEY • Phone: +90 232 311 10 10 • e-mail: intrec@mail.ege.edu.tr