Description of Individual Course Units
Course Unit CodeCourse Unit TitleType of Course UnitYear of StudySemesterNumber of ECTS Credits
404004742006CLINICAL CHEMISTRYElective483
Level of Course Unit
First Cycle
Objectives of the Course
Clinical chemistry is the application of the science of chemistry to the understanding of the human health and disease. The course includes the basic analytical physiology of the various organs with emphasis on the use of the findings of the clinical chemistry laboratory in the evaluation of their function in disease and serves as a practicing biochemist who wishes to work in this area.
Name of Lecturer(s)
Assoc. Prof. Dr. Serap Evran
Learning Outcomes
1Understand the medical, scientific and technological principles of Clinical Chemistry and its interrelationship with other disciplines.
2Develop their clinical, scientific and research skills
3Be able to assess the effectiveness of individual tests, strategies and protocols for the investigation of disease
4Acquire a detailed knowledge of laboratory techniques and instrumentation
5Follow up recent developments including molecular diagnostics, robotics, self testing
Mode of Delivery
Face to Face
Prerequisites and co-requisities
None
Recommended Optional Programme Components
None
Course Contents
Description and methods of clinical biochemistry, preparation of samples, diabetes and acute metabolic diseases in diabetes hypoglycemia, glycogen storage diseases, lipid metabolism and hyperlipoproteinemia, amino acid and protein metabolism disease, enzyme levels in plasma and their differentiations in some diseases, hyperurisemia, gut diseases, phorphirias, pigment metabolism and jaundice.
Weekly Detailed Course Contents
WeekTheoreticalPracticeLaboratory
1Definition of clinical chemistry. Biochemical testing. Functions of blood. Preparation of plasma and serum samples. Blood specimen collection. AnticoagulantsIntroduction
2Urine specimen collection. Physical properties of urine. Chemical analysis of urine. Other specimens used for clinical laboratory tests. Internet search-reporting
3Sources of error in clinical laboratories. Effects of gender, age, environment, smoking, alcohol, drugs, food intake on analysis. Problem solving
4Carbohydrate metabolism disorders. Hormonal control of blood sugar level. Actions of insulin. Laboratory analysis of insulin, C-peptide and glucagonInternet search-reporting and problem solving
5Diabetes mellitus. Laboratory tests for diagnosis of diabetes mellitus. Analysis of glucose in blood and urine. Glycogen storage diseases. Ketoacidosis. Hypoglycemia. Problem solving
6Plasma proteins. Disorders of amino acid and protein metabolism. ImmunoglobulinsInternet search-reporting
7Diseases of hemoglobin metabolism. Analysis of iron binding capacity. Clinically important porphyrins. Problem solving
8Midterm examMidterm exam
9Diseases of lipid metabolism. Lipoproteins. Definitions of HDL, VLDL, LDL cholesterol.Problem solving
10Tests for diagnosis of lipid metabolism diseases and analysis of test results. Internet search-reporting
11Enzymes in clinical chemistryInternet search-reporting
12Liver and kidney function tests. Markers of heart and muscle diseases. Internet search-reporting
13Hormones. Analysis of thyroid function. TSH test.Problem solving
14Tumor markers in clinical chemistryProblem solving
15Latest developments in clinical chemistry laboratory testsProblem solving
16Final examFinal exam
Recommended or Required Reading
Clinical Chemistry: Theory, Analysis, Correlation, 4th ed. Lawrence A. Kaplan, Amadeo J. Pesce, and Steven C. Kazmierczak, editors. St. Louis, MO: Mosby, 2003 Clinical Chemistry: A Laboratory Perspective Wendy L. Arneson, Jean M. Brickell, 2007.
Planned Learning Activities and Teaching Methods
Activities are given in detail in the section of "Assessment Methods and Criteria" and "Workload Calculation"
Assessment Methods and Criteria
Term (or Year) Learning ActivitiesQuantityWeight
SUM0
End Of Term (or Year) Learning ActivitiesQuantityWeight
SUM0
SUM0
Language of Instruction
Turkish
Work Placement(s)
None
Workload Calculation
ActivitiesNumberTime (hours)Total Work Load (hours)
Midterm Examination199
Final Examination11010
Attending Lectures14228
Problem Solving717
Report Preparation6636
TOTAL WORKLOAD (hours)90
Contribution of Learning Outcomes to Programme Outcomes
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LO15    55   5         5 
LO2555  5   55       5 5 
LO3  5                   
LO4 5    5 55    5       
LO5   5        5 5       
* Contribution Level : 1 Very low 2 Low 3 Medium 4 High 5 Very High
 
Ege University, Bornova - İzmir / TURKEY • Phone: +90 232 311 10 10 • e-mail: intrec@mail.ege.edu.tr