Description of Individual Course Units
Course Unit CodeCourse Unit TitleType of Course UnitYear of StudySemesterNumber of ECTS Credits
9101036012005Structure and Function of Biological MembranesElective117
Level of Course Unit
Third Cycle
Language of Instruction
Turkish
Objectives of the Course
To give an understanding the structure and function of biological membranes
Name of Lecturer(s)
Prof. Dr. Seçil Önal
Learning Outcomes
1Be able to understand and compare the composition of membranes
2Knowledge of basic processes underlying membrane biogenesis and of membrane dynamics in a cell biological context
3Identify the types and characteristics of membrane proteins present in cell membrane
4Gain understanding of the variety of ways in which solutes and water can be transported across membranes
Mode of Delivery
Face to Face
Prerequisites and co-requisities
None
Recommended Optional Programme Components
None
Course Contents
Biological membranes and structures, chemical compositions, principles of membrane organization, cell membranes, biogenesis of cell membranes, molecular motion in membranes, membrane fluidity, membrane proteins, protein-lipid interactions, techniques for structure determination of membranes, transport across membrane and transport types, energetics of membranes
Weekly Detailed Course Contents
WeekTheoreticalPracticeLaboratory
1Introduction to biological membranes, principles of membrane structure
2Lipid components of membranes; lipid classification and chemical features, lipid composition, monolayers, bilayers, micelles, liposomes and biomembranes
3Protein components of membranes; types, structure, arrangement and properties of membrane proteins
4Hydropathy profiles and secondary structure predictions, folding of membrane proteins
5Membrane protein dynamics, rotational and translational diffusion, measurement techniques
6Protein-lipid interactions and membrane function
7Transport across the membrane, electron transport driven systems, carriers, channels
8Mid-term Exam
9H+ translocation by the mitochondrial respiratory chain, chemiosmotic hypothesis, proton translocation by complexes
10Light-driven H+ translocation, electron transport in thylakoids, bacterial photosynthetic reaction centre, bacteriorhodopsin
11F-, V-, P-type ATPases and ATP synthesis, structure of F-type ATPases and molecular mechanism
12Primary ion pumps and the generation of ionic gradients, structure and function of P-type ATPases, ABC transporters
13Carrier mediated transport, molecular mechanism
14Biological aspects of channel function, ion channels, ion carrying and channel forming ionophores, ligant-gated channel, voltage-gated channels, water channels, aquaporins and types
15Project presentation
16Final Exam
Recommended or Required Reading
C.K. Mathews, K.E. van Holde, K.G. Ahern, Biochemistry, Addison Westley Haugman Inc. (2000). D.L. Nelson, M.M. Cox, Lehninger, Principles of Biochemistry, Worth Publishing (2000). D. Voet, J.G. Voet, Biochemistry Wiley VCH (1995)
Planned Learning Activities and Teaching Methods
Activities are given in detail in the sections of "Assessment Methods and Criteria" and "Workload Calculation".
Assessment Methods and Criteria
Term (or Year) Learning ActivitiesQuantityWeight
Midterm Examination1100
SUM100
End Of Term (or Year) Learning ActivitiesQuantityWeight
Final Sınavı1100
SUM100
Term (or Year) Learning Activities40
End Of Term (or Year) Learning Activities60
SUM100
Work Placement(s)
None
Workload Calculation
ActivitiesNumberTime (hours)Total Work Load (hours)
Midterm Examination122
Final Examination122
Attending Lectures14228
Report Presentation12020
Project Preparation12525
Project Presentation122
Self Study14570
Reading14456
TOTAL WORKLOAD (hours)205
Contribution of Learning Outcomes to Programme Outcomes
PO
1
PO
2
PO
3
PO
4
PO
5
PO
6
PO
7
PO
8
PO
9
PO
10
PO
11
PO
12
LO15   2       
LO25  4  4 3 3 
LO35 3 13      
LO454    2    3
* Contribution Level : 1 Very low 2 Low 3 Medium 4 High 5 Very High
 
Ege University, Bornova - İzmir / TURKEY • Phone: +90 232 311 10 10 • e-mail: intrec@mail.ege.edu.tr