Description of Individual Course Units
Course Unit CodeCourse Unit TitleType of Course UnitYear of StudySemesterNumber of ECTS Credits
9101036031998Membrane ProteinsElective117
Level of Course Unit
Third Cycle
Language of Instruction
Turkish
Objectives of the Course
Define and classification of membrane proteins, investigate the membrane proteins in transport and biological events
Name of Lecturer(s)
Prof. Dr. Seçil Önal
Learning Outcomes
1Identify the various classes of membrane proteins and to describe the differences between them
2Knowledge on molecular dynamics of membrane proteins
3Gain an ability to compare the methods of analysis of membrane proteins
4Understand the structure and composition of biological membranes
5Gain an ability to design and develop strategies for purification and crystallization of membrane proteins
Mode of Delivery
Face to Face
Prerequisites and co-requisities
None
Recommended Optional Programme Components
None
Course Contents
Molecular constituents of biological membranes, structure and function of membrane proteins, classification of membrane proteins, topology of membrane proteins, solubilization, crystallization, analysis and different characteristics of membrane proteins, special membrane proteins and releated biological events
Weekly Detailed Course Contents
WeekTheoreticalPracticeLaboratory
1 Introduction to biological membranes, components of cell membrane
2Principles of membrane organization and biogenesis of cell membrane
3 Structure and properties of lipid bilayers, molecular motion in membrane and membrane fluidity
4Proteins in biological membranes, types and arrangement of membrane proteins
5 Hydropathy profiles and secondary structure predictions, folding motifs of membrane proteins
6 Protein-lipid interactions in membranes
7 Membrane topology and insertion of membrane proteins
8Mid-term Exam
9Solubilisation, purification and characterisation of membrane proteins
10 Crystallisation of membrane proteins
11 Transport across membranes and membrane proteins
12Transport types, diffusion, mechanism of simple and facilitated diffusion, active and passive transport
13 Special membrane proteins, structures and releated biological events
14Membrane energetics, chloroplast and mitochondri membranes and energy tranduction
15Project presentation
16Final Exam
Recommended or Required Reading
R. Grisshammer, S.K. Buchanan, Structural Biology of membrane proteins, RSC Publishing (2008) C. Hunte, G. Von Jagow, H. Schagger, Membrane Protein Purification and Crystallization; a practical guide, Academic Pres (2003)
Planned Learning Activities and Teaching Methods
Activities are given in detail in the sections of "Assessment Methods and Criteria" and "Workload Calculation".
Assessment Methods and Criteria
Term (or Year) Learning ActivitiesQuantityWeight
Midterm Examination1100
SUM100
End Of Term (or Year) Learning ActivitiesQuantityWeight
Final Sınavı1100
SUM100
Term (or Year) Learning Activities40
End Of Term (or Year) Learning Activities60
SUM100
Work Placement(s)
None
Workload Calculation
ActivitiesNumberTime (hours)Total Work Load (hours)
Midterm Examination122
Final Examination122
Attending Lectures14228
Report Preparation12525
Project Preparation12525
Project Presentation122
Self Study14684
Reading14342
TOTAL WORKLOAD (hours)210
Contribution of Learning Outcomes to Programme Outcomes
PO
1
PO
2
PO
3
PO
4
PO
5
PO
6
PO
7
PO
8
PO
9
PO
10
PO
11
PO
12
LO154       3  
LO254  3       
LO32 3    2 2  
LO454  4 4  2  
LO5   4  2 3  3
* Contribution Level : 1 Very low 2 Low 3 Medium 4 High 5 Very High
 
Ege University, Bornova - İzmir / TURKEY • Phone: +90 232 311 10 10 • e-mail: intrec@mail.ege.edu.tr