Description of Individual Course Units
Course Unit CodeCourse Unit TitleType of Course UnitYear of StudySemesterNumber of ECTS Credits
9101036082003Biochemistry of Free RadicalsElective128
Level of Course Unit
Third Cycle
Language of Instruction
Turkish
Objectives of the Course
This course is designed to give students an understanding of the fundamental aspects of free radicals and their role in disease and antioxidant defence systems against free radicals
Name of Lecturer(s)
Assoc. Prof. Dr.Şenay Şanlıer
Learning Outcomes
1Gain understanding and experience of antioxidant mechanisms
2Be able to interpret the role of antioxidants in prevention of diseases
3Be able to read scientific literature searching and interpret the knowledge on free radicals
4Gain understanding and experience of reaction mechanisms for free radicals
5Be able to follow up recent data
6Be able to learn enzymic and non-enzymic antioxidants
7Be able to learn free radicals induced damage
8Be able to learn phytochemicals as antioxidants
9Be able to learn free radicals
10Be able to interpret defence systems against free radicals
11Be able to understandoxidative damage on macromolecular
Mode of Delivery
Face to Face
Prerequisites and co-requisities
None
Recommended Optional Programme Components
None
Course Contents
Concept and formation mechanisms of radicals, radical species, radical reactions, cell damage with free radicals, free oxygen radicals, radicalic species, the effect of oxidative damage on macromolecular, defence systems against free radicals, antioxidant defence, the mechanisms of antioxidant
Weekly Detailed Course Contents
WeekTheoreticalPracticeLaboratory
1Free radicals biochemistry; radicalic species
2Formation of free radical, endogen effect, exogen effect
3Effect mechanisms of free radicals
4Damage of free radical; lipid peroxidation, damage of DNA, damage of proteins
5Effect of oxidative damage on macromolecules
6Antioxidants and antioxidant species
7Antioxidant enzyme; catalase, SOD, glutathione peroxidase, glutathione reductase, glutathione-S-transferase, glutathione transferase
8Mid-term exam
9Antioxidant molecules; glutathione, vitamine A,C,E, flavonoids
10Antioxidant molecules; melatoine, uric acid and other antioxidant molecules
11Disease and antioxidants
12Role of antioxidants in prevention of diseases
13Phytochemicals as antioxidants
14Project presentation
15Project presentation
16Final exam
Recommended or Required Reading
B.Hallwell, J.M.C. Gutterdge, “Free Radicals in Biology and Medicine”, fourth edition,Oxford Science Publications, 2007. “Free Radical Biology and Medicine”,Elsevier journal, vol 44-49, 2008-2010. G.S.Foote,”Active Oxygen in Chemistry”, Blockie, London,1995. H.W.S. Chan,”Autooxidation of Unsaturated Lipids”, Norwich, UK, 1986
Planned Learning Activities and Teaching Methods
Activities are given in detail in the sections of "Assessment Methods and Criteria" and "Workload Calculation".
Assessment Methods and Criteria
Term (or Year) Learning ActivitiesQuantityWeight
Midterm Examination1100
SUM100
End Of Term (or Year) Learning ActivitiesQuantityWeight
Final Sınavı1100
SUM100
Term (or Year) Learning Activities40
End Of Term (or Year) Learning Activities60
SUM100
Work Placement(s)
None
Workload Calculation
ActivitiesNumberTime (hours)Total Work Load (hours)
Midterm Examination11515
Final Examination12525
Attending Lectures14228
Report Preparation21530
Project Preparation31030
Project Presentation326
Criticising Paper4416
Reading14570
TOTAL WORKLOAD (hours)220
Contribution of Learning Outcomes to Programme Outcomes
PO
1
PO
2
PO
3
PO
4
PO
5
PO
6
PO
7
PO
8
PO
9
PO
10
PO
11
PO
12
LO15           
LO2  5         
LO34  5      5 
LO4 5  4       
LO5        5   
LO6          5 
LO7           5
LO84          5
LO95           
LO10  5         
LO11  5         
* Contribution Level : 1 Very low 2 Low 3 Medium 4 High 5 Very High
 
Ege University, Bornova - İzmir / TURKEY • Phone: +90 232 311 10 10 • e-mail: intrec@mail.ege.edu.tr