Description of Individual Course Units
Course Unit CodeCourse Unit TitleType of Course UnitYear of StudySemesterNumber of ECTS Credits
9101036152003Metabolic Regulation SystemsElective117
Level of Course Unit
Third Cycle
Language of Instruction
Turkish
Objectives of the Course
Metabolic pathways of living systems and their interrelation ships, including control mechanisms, the effects of hormonal and nutritional status on the activity of these major pathways
Name of Lecturer(s)
Prof. Dr. Seçil Önal
Learning Outcomes
1Discuss general issues releated to regulation and integration of metabolic processes
2Understand the fundamental principles of various metabolic pathways and their regulation
3Describe the basic mechanisms that drive the life processes
4Describe and discuss the use of various metabolites as energy sources
5Identify the subcellular location of steps of metabolic pathways
Mode of Delivery
Face to Face
Prerequisites and co-requisities
None
Recommended Optional Programme Components
None
Course Contents
Biochemical regulation, major metabolic pathways and control of them, carbohydrate, lipid and nitrogen metabolism and their regulation and integration
Weekly Detailed Course Contents
WeekTheoreticalPracticeLaboratory
1 Metabolism, anabolism and catabolism, metabolic reactions, anabolic and catabolic reactions
2Metabolic pathways, biochemical regulation, regulation of metabolic pathways
3Aminoacid and protein metabolism; aminoacid biosynthesis and degradation, PDLP reactions, urea cycle and regulation, conversion of aminoacids to specialized products
4 Nucleotide metabolism; synthesis and catabolism of purines and pyrimidines and regulation
5Bioenergetic, crebs cycle, allosteric and hormonal regulation, electron transport and oxidative phosphorylation, electron transport complexes, generation of proton gradient, ATP synthase
6 Carbohydrate metabolism 1: Mechanism and regulation of glycolysis, fermentation of lactic acid, pentose phosphate pathway and glyoxylate cycle, fate of pyruvate
7Carbohydrate metabolism 2: Glycogen metabolism, regulation of blood glucose, hormonal regulation
8Mid-term Exam
9 Lipid metabolism 1: digestion and adsorption of lipids, lipolysis and β-oxidation of fatty acids
10Lipid metabolism 2: Synthesis and energetic role of ketonebodies, synthesis of fatty acids, glycerophospholipids, sfingolipids and cholesterol, steroid hormones, lipoproteins, regulation of lipid metabolism
11 Integration of metabolism 1: overview, hormonal signal transduction and regulation, schemes of feeding-fasting cycles, well-fed and starvation states
12Integration of metabolism 2: well-fed state, signal transduction and regulation, glycolysis, hexosemonophosphate pathway, glycogenesis, de novo fatty acid synthesis, lipogenesis, lipoprotein transport and fat storage in adipose tissue
13 Integration of metabolism 3: Fasting, signal transduction and regulation, hepatic glycogenolysis, gluconeogenesis, lipolysis, β-oxidation of fatty acids in liver
14Integration of metabolism 4: Starvation, signal transduction and regulation, gluconeogenesis, skeletal muscle catabolism, urea cycle, lipolysis, β-oxidation of fatty acids, ketogenesis and metabolism of ketone bodies
15 Project presentation
16Final Exam
Recommended or Required Reading
K. N. Frayn, Metabolic Regulation, A Human Perspective, Portland Pres (2001) Priciples of Biochemistry, Lehninger, 5th ed. W.H. Freeman (2008)
Planned Learning Activities and Teaching Methods
Activities are given in detail in the sections of "Assessment Methods and Criteria" and "Workload Calculation".
Assessment Methods and Criteria
Term (or Year) Learning ActivitiesQuantityWeight
Midterm Examination1100
SUM100
End Of Term (or Year) Learning ActivitiesQuantityWeight
Final Sınavı1100
SUM100
Term (or Year) Learning Activities40
End Of Term (or Year) Learning Activities60
SUM100
Work Placement(s)
None
Workload Calculation
ActivitiesNumberTime (hours)Total Work Load (hours)
Midterm Examination12020
Final Examination12525
Attending Lectures14342
Report Presentation11515
Project Preparation12020
Project Presentation11515
Self Study41040
Reading41040
TOTAL WORKLOAD (hours)217
Contribution of Learning Outcomes to Programme Outcomes
PO
1
PO
2
PO
3
PO
4
PO
5
PO
6
PO
7
PO
8
PO
9
PO
10
PO
11
PO
12
LO14 4   5   3 
LO254  54  4  4
LO353 4   4 3 3
LO44  4 4      
LO54   4      4
* Contribution Level : 1 Very low 2 Low 3 Medium 4 High 5 Very High
 
Ege University, Bornova - İzmir / TURKEY • Phone: +90 232 311 10 10 • e-mail: intrec@mail.ege.edu.tr