Description of Individual Course Units
Course Unit CodeCourse Unit TitleType of Course UnitYear of StudySemesterNumber of ECTS Credits
9101036281998Mechanism of Enzyme CatalysisElective128
Level of Course Unit
Third Cycle
Language of Instruction
Turkish
Objectives of the Course
The aims of this course are, to provide a theoretical understanding of the nature, structure, catalytic and kinetic properties of enzymes. By the end of the course, the student should be able to understand the importance of enzymes and their utilization classify enzymes, appreciate methods used to study active sites and the mechanism of enzyme catalysis.
Name of Lecturer(s)
Prof. Dr. Erhan Dinçkaya
Learning Outcomes
1Be able to read scientific literature on mechanisms of enzyme catalysis
2Be able to communicate enzyme mechanisms and other scientific areas.
3Gain an ability to explain mechanisms of enzyme catalysis
4Gain an ability to write scientific reports accurately and concisely on enzyme mechanisms.
5Gain understanding appreciate methods used to study active sites
6Be able to understand the nature, structure, catalytic and kinetic properties of enzymes.
Mode of Delivery
Face to Face
Prerequisites and co-requisities
None
Recommended Optional Programme Components
None
Course Contents
Enzymes classification; rules for classification and nomenclature, enzyme structure, the active centre, enzyme mechanisms; mechanisms of oxidoreductases, transferases, hydrolases, lyases, isomerases and ligases.
Weekly Detailed Course Contents
WeekTheoreticalPracticeLaboratory
1Classification of enzymes; rules for classification and nomenclature,
2Enzyme structure
3Active centre
4Stereochemistry of enzyme catalysis
5Chemical mechanisms of enzyme catalysis : Orientation,covalent catalysis
6Chemical mechanisms of enzyme catalysis :General acid-base catalysis, metal- ion catalysis
7Chemical mechanisms of enzyme catalysis:Conformational strain ad others
8Mid-term exam
9Effect of pH on enzyme catalysis
10Mechanisms of oxidoreductases, Mechanisms of transferases
11Mechanisms of hydrolases, Mechanisms of lyases
12Mechanisms of isomerases
13Mechanisms of ligases
14 Project presentation
15 Project presentation
16 Final exam
Recommended or Required Reading
A. Ferst, “Structure and Mechanism in Protein Science”, W.H.Freeman and Company, (2000) M. Dixon, E. C.Webb, “Enzymes”, Longman Group Limited, (1979)
Planned Learning Activities and Teaching Methods
Activities are given in detail in the sections of "Assessment Methods and Criteria" and "Workload Calculation".
Assessment Methods and Criteria
Term (or Year) Learning ActivitiesQuantityWeight
Midterm Examination1100
SUM100
End Of Term (or Year) Learning ActivitiesQuantityWeight
Final Sınavı1100
SUM100
Term (or Year) Learning Activities40
End Of Term (or Year) Learning Activities60
SUM100
Work Placement(s)
None
Workload Calculation
ActivitiesNumberTime (hours)Total Work Load (hours)
Midterm Examination122
Final Examination122
Attending Lectures14228
Report Preparation21020
Report Presentation212
Self Study14456
Individual Study for Mid term Examination12323
Individual Study for Final Examination14040
Reading14228
TOTAL WORKLOAD (hours)201
Contribution of Learning Outcomes to Programme Outcomes
PO
1
PO
2
PO
3
PO
4
PO
5
PO
6
PO
7
PO
8
PO
9
PO
10
PO
11
PO
12
LO1   4    4   
LO24 4 5       
LO3           5
LO4          4 
LO5      4     
LO65           
* Contribution Level : 1 Very low 2 Low 3 Medium 4 High 5 Very High
 
Ege University, Bornova - İzmir / TURKEY • Phone: +90 232 311 10 10 • e-mail: intrec@mail.ege.edu.tr