Description of Individual Course Units
Course Unit CodeCourse Unit TitleType of Course UnitYear of StudySemesterNumber of ECTS Credits
9101036022011Biotransformations Elective128
Level of Course Unit
Third Cycle
Language of Instruction
Turkish
Objectives of the Course
The aim of the course is to be aware of the range of the transformations that are catalysed by enzymes. The objectives are to understand the advantages and disadvantages of using biocatalysts, to be familiar with the different types of biocatalysis, which can be carried out, and to be aware that enzymes can be used in organic synthesis and their use in industry
Name of Lecturer(s)
Assoc. Prof. Dr.Ali KILINÇ
Learning Outcomes
1Be able to design the synthesis of the Biochemical products in organic solvents
2Be able to develop Biotransformation processes
3Be able to follow up the recent literature
4Be able to examine and compare the advantages/disadvantages of the methods used
5Be able to identify, understand and explain Biotransformation
6Gain the ability to choose the appropriate method
7Be able to do Individual and group work
8Be able to examine, comparison and interpretation of the research results
Mode of Delivery
Face to Face
Prerequisites and co-requisities
None
Recommended Optional Programme Components
None
Course Contents
Biotransformation in Organic Synthesis: Biocatalytic applications of hydrolytic reactions, reductions, oxidations, And addition and elimination reactions. Industrial Biotransformations: History of industrial biotransformations, enzyme classification, basic bioreaction engineering, processes
Weekly Detailed Course Contents
WeekTheoreticalPracticeLaboratory
1Introduction to BiotransformationsLiterature survey for enzymatic oxidation and reduction reactions
2Industrial Biotransformations: - History of industrial biotransformations, - Enzyme classification, basic bioreaction engineering, processes. Literature survey for enzymatic oxidation and reduction reactions
3Industrial Biotransformations: - Enzyme classification, basic bioreaction engineering, processes. enzymatic oxidation and reduction reactions with oxidoreductase
4Biotransformation in Organic Synthesis: Biocatalytic applications - Biocatalytic applications of hydrolytic reactions, enzymatic oxidation and reduction reactions with oxidoreductase
5Biocatalytic applications - Reductions and oxidations reactions.enzymatic oxidation and reduction reactions with oxidoreductase
6Biocatalytic applications - Addition and Elimination reactions.enzymatic oxidation and reduction reactions with oxidoreductase
7Special Techniques: Enzymes in Organic Solvents - Ester Synthesis - Lactone Synthesis - Amide Synthesisenzymatic oxidation and reduction reactions with oxidoreductase
8Mid-term ExamProblem Discussion
9Selected topics of biotransformationsAnalysis of biotransformation products
10Selected topics of biotransformationsAnalysis of biotransformation products
11Selected topics of biotransformationsAnalysis of biotransformation products
12Selected topics of biotransformationsProblem Discussion
13Project presentationData evaluation
14Project presentationData evaluation
15Project presentationData evaluation
16Final Exam
Recommended or Required Reading
1) K. Faber, “Biotransformations”, Springer-Verlag Berlin and Heidelberg, (2000) 2) K. Faber, “Biotransformations in Organic Chemistry”, 2nd Edition, Springer-Verlag Berlin and Heidelberg, (1995) 3) J. R. Hanson, “An Introduction to Biotransformations in Organic Chemistry”, W. H. Freeman and Stockton, (1995) 4) A. Telefoncu, “Biyoteknoloji”, E.Ü. Fen Fakültesi Yayınları, No:152, (1995)
Planned Learning Activities and Teaching Methods
Activities are given in detail in the sections of "Assessment Methods and Criteria" and "Workload Calculation".
Assessment Methods and Criteria
Term (or Year) Learning ActivitiesQuantityWeight
Midterm Examination1100
SUM100
End Of Term (or Year) Learning ActivitiesQuantityWeight
Final Sınavı1100
SUM100
Term (or Year) Learning Activities40
End Of Term (or Year) Learning Activities60
SUM100
Work Placement(s)
None
Workload Calculation
ActivitiesNumberTime (hours)Total Work Load (hours)
Midterm Examination122
Final Examination122
Attending Lectures14798
Laboratory10330
Discussion428
Question-Answer14228
Experiment10330
Report Preparation10440
Report Presentation10440
Criticising Paper428
Self Study4624
Individual Study for Homework Problems4624
Individual Study for Mid term Examination11010
Individual Study for Final Examination11010
Report10550
Laboratory Examination122
TOTAL WORKLOAD (hours)406
Contribution of Learning Outcomes to Programme Outcomes
PO
1
PO
2
PO
3
PO
4
PO
5
PO
6
PO
7
PO
8
PO
9
PO
10
PO
11
PO
12
LO155 4554  4 4
LO244 44333 4 5
LO3   43   5 3 
LO4 5  344  4  
LO55   4      4
LO6444 34     4
LO7   5   5    
LO84  4355   5 
* Contribution Level : 1 Very low 2 Low 3 Medium 4 High 5 Very High
 
Ege University, Bornova - İzmir / TURKEY • Phone: +90 232 311 10 10 • e-mail: intrec@mail.ege.edu.tr