Description of Individual Course Units
Course Unit CodeCourse Unit TitleType of Course UnitYear of StudySemesterNumber of ECTS Credits
9103106102011Genetic Engineering and Microbial Engineering Elective129
Level of Course Unit
Third Cycle
Objectives of the Course
The aim of the course is to make students aware of genetic engineering and microbial engineering.
Name of Lecturer(s)
Prof.Dr. Rengin ELTEM
Learning Outcomes
1To have knowledge about of the using nucleic acids as therapeutic agents
2Learning of advanced concepts of genetic engineering and microbial engineering
3To have knowledge about of the using mamalian protein as therapeutic agents
4To have knowledge about of the enzymes as therapeutic agents
Mode of Delivery
Face to Face
Prerequisites and co-requisities
None
Recommended Optional Programme Components
None
Course Contents
Molecular biotechnology,gen expressions in prokaryotes, pharmaceuticals as therapeutic agents, enzymes as therapeutic agents, nucleic acids as therapeutic agents, antibiotic producing of recombinant microorganisms.
Weekly Detailed Course Contents
WeekTheoreticalPracticeLaboratory
1Technology of recombinant DNA. Genetic engineering and biotechnology Comercialization of molecular biotechnology
2Molecular biotechnology biologic systems: Ideal hosts used in genetic engineering.
3Secretion pathways in prokaryotic and eukaryotic organisms
4Eukaryotic and prokaryotic promotors. Gene expression from strong and regulated promotors.
5Fusion proteins, Increasing protein stability. overcoming of oxygen limitation
6 Increasing secretion (L-form bacteria). Metabolic load
7Pharmaceuticals as therapeutic agents: Human insulin, human interferons
8Midterm exam
9Pharmaceuticals as therapeutic agents : Human growth hormone, Tumor necrosis factor
10Enzymes as therapeutic agents: Alginate lyase, phenylalanine ammonia lyase
11Nucleic acids as therapeutic agents: Antisense RNA, Antisense oligonucleotides, ribozymes, interfering RNAs
12Synthesis of comercial products by recombinant microorganisms. Production of recombinant enzymes
13Antibiotic producing of recombinant microorganisms.
14Project presentation
15Project presentation
16Final Exam
Recommended or Required Reading
1.Tortora, G. J., Funke, B. R., Case, C. L., “Microbiology an Introduction”, Tenth Ed.,Pearson Education, (2010). 2.Schaechter, M. “Encyclopedia of Microbiology” Third Ed., Elsevier, (2009). 3.Okafor, N. “Modern Industrial Microbiology and Biotechnology”, Science Publishers, (2007). 4.Madigan, M. T. Martinko, J. M., Parker, J., “Brock Biology of Microorganisms”, Pearson Education, (2006). 5.Glick, B.R. and Pasternak, J.J., (2003). Molecular Biotechnology: Principles& Applications of Recombinant DNA, 3rd Ed. The Book Place. 6.Glazer, A.N., and Nikaido, H., Microbial Biotechnology: Fundamentals of Applied Microbiology, W.H.Freeman and Company, New York, 662 p, 1995.
Planned Learning Activities and Teaching Methods
Activities are given in detail in the section of "Assessment Methods and Criteria" and "Workload Calculation"
Assessment Methods and Criteria
Term (or Year) Learning ActivitiesQuantityWeight
SUM0
End Of Term (or Year) Learning ActivitiesQuantityWeight
SUM0
SUM0
Language of Instruction
Turkish
Work Placement(s)
None
Workload Calculation
ActivitiesNumberTime (hours)Total Work Load (hours)
Midterm Examination122
Final Examination122
Attending Lectures14228
Project Preparation13535
Project Presentation122
Individual Study for Mid term Examination13939
Individual Study for Final Examination15050
Reading148112
TOTAL WORKLOAD (hours)270
Contribution of Learning Outcomes to Programme Outcomes
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1
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2
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5
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6
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7
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8
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9
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10
PO
11
PO
12
PO
13
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* Contribution Level : 1 Very low 2 Low 3 Medium 4 High 5 Very High
 
Ege University, Bornova - İzmir / TURKEY • Phone: +90 232 311 10 10 • e-mail: intrec@mail.ege.edu.tr