Description of Individual Course Units
Course Unit CodeCourse Unit TitleType of Course UnitYear of StudySemesterNumber of ECTS Credits
9103106372014Molecular Biology of CancerElective118
Level of Course Unit
Third Cycle
Objectives of the Course
To have an experimental and research knowledge for investigating molecular mechanism of cancer
Name of Lecturer(s)
Prof. Dr. Kemal Sami Korkmaz
Learning Outcomes
1Understanding the cell cycle and the molecular mechanisms of check points
2Understanding the oncogenes and their activation
3Understanding the cell cycle, and tumor suppressors and their repression
4RTKinases and the mechanisms of activation
5DNA damage and signaling, DD Response
6Cancer therapy targets, methods of targeting and intervention
7
Mode of Delivery
Face to Face
Prerequisites and co-requisities
None
Recommended Optional Programme Components
Familiarity to Advanced level of cellular and molecular biology approaches and knowledge
Course Contents
Given in a weekly course content
Weekly Detailed Course Contents
WeekTheoreticalPracticeLaboratory
1Introduction to Cancer
2DNA structure and stability, mutations, Carcinogens, repair mech.
3Regulation of Gene expression, general transcription factors and the regulation of Chromatin remodeling
4Regulation of Gene expression, tissue specific transcription factors and the regulation of Chromatin remodeling
5Growth Factor signaling and the Oncogenes, Kinases, RAS signaling
6Growth Factor signaling and the tumor supressors, RB, p53 pathways
7the mechanisms of Apoptosis
8Midterm Exam
9Stem cells and the Wnt, Hh pathways
10Metastasis, extravasation, angiogenesis
11Matrix metalloproteinases
12Inflammation and the cancer, ROS mediated DNA damage
13Steroid reseptors and their role in cancer progression
14Prostat cancer and the androgen receptor
15Intervention therapies and the new modalities, approaches
16Final Exam
Recommended or Required Reading
Molecular Biology of Cancer, Lauren Pecorino, Oxford press, current articles (pubmed)
Planned Learning Activities and Teaching Methods
Assessment Methods and Criteria
Term (or Year) Learning ActivitiesQuantityWeight
Midterm Examination1100
SUM100
End Of Term (or Year) Learning ActivitiesQuantityWeight
Final Sınavı1100
SUM100
Term (or Year) Learning Activities40
End Of Term (or Year) Learning Activities60
SUM100
Language of Instruction
Turkish
Work Placement(s)
None
Workload Calculation
ActivitiesNumberTime (hours)Total Work Load (hours)
Midterm Examination122
Final Examination122
Attending Lectures15230
Individual Study for Mid term Examination159135
Individual Study for Final Examination17171
TOTAL WORKLOAD (hours)240
Contribution of Learning Outcomes to Programme Outcomes
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1
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7
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8
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9
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10
PO
11
PO
12
PO
13
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* Contribution Level : 1 Very low 2 Low 3 Medium 4 High 5 Very High
 
Ege University, Bornova - İzmir / TURKEY • Phone: +90 232 311 10 10 • e-mail: intrec@mail.ege.edu.tr